Haemaccel (Polygeline)

Haemaccel is indicated for clinical situations where rapid plasma volume expansion is required.

• Treatment of hypovolemia due to acute blood loss or dehydration.
• Management of circulatory shock when immediate volume support is needed.
• Intra‑operative fluid replacement to maintain adequate intravascular volume.
• Adjunct therapy during major surgery to prevent hypotension.
• Support for patients undergoing dialysis who require plasma expansion.
• Use in trauma care to stabilize patients before definitive hemorrhage control.

The safety profile of Haemaccel includes a range of observed adverse reactions, which are generally categorized by frequency and severity.

Common

• Mild, transient fever or chills occurring shortly after infusion.
• Temporary elevation of blood pressure that resolves without intervention.
• Local irritation or pain at the intravenous infusion site.
• Nausea or mild gastrointestinal discomfort during or after administration.
• Headache or dizziness that subsides within a few hours.

Serious

• Anaphylactic or severe allergic reactions, including rash, bronchospasm, or hypotension.
• Pulmonary edema resulting from fluid overload, especially in patients with cardiac dysfunction.
• Renal impairment or decreased kidney function in susceptible individuals.

When using Haemaccel, clinicians should consider several precautionary measures to minimize risks and ensure appropriate patient selection.

• Assess cardiac and renal function before administration, as fluid overload may exacerbate heart failure or kidney disease.
• Avoid rapid infusion rates; follow recommended administration guidelines to reduce the chance of pulmonary edema.
• Use caution in patients with known hypersensitivity to polygeline or other gelatin-derived products.
• Monitor vital signs and fluid balance closely during and after infusion.
• Do not administer concomitantly with large volumes of crystalloid solutions without adjusting total fluid input.

Haemaccel may interact with other medications or clinical conditions; awareness of these interactions helps guide safe use.

Avoid

• Avoid concurrent use with other colloid volume expanders, as combined oncotic load can increase risk of fluid overload.
• Do not give with medications known to cause severe allergic reactions in gelatin-sensitive patients.

Use with caution

• Use cautiously with diuretics, which may alter fluid balance and require adjustment of infusion volume.
• Co‑administration with anticoagulants may enhance bleeding risk due to dilutional effects; monitor coagulation parameters.
• Caution is advised when combined with drugs that affect renal function, such as aminoglycosides or NSAIDs, to prevent further kidney impairment.