Haemate (Human Coagulation Factor Viii, Human Von Willebrand Factor)

Haemate is used to manage bleeding disorders that involve deficiency of factor VIII and von Willebrand factor.

• Routine prophylaxis in patients with severe hemophilia A to maintain trough factor levels.
• Treatment of acute bleeding episodes in hemophilia A.
• Management of surgical or invasive procedures in hemophilia A to prevent peri‑operative hemorrhage.
• Prevention and control of bleeding in patients with von Willebrand disease, including type 1, 2, and 3.
• Support for patients with combined factor VIII and von Willebrand factor deficiency.

Adverse reactions reported with Haemate are generally related to the infusion or immune response.

Common

• Mild fever or chills during infusion.
• Headache or fatigue.
• Nausea or mild abdominal discomfort.
• Local site reactions such as redness or swelling.

Serious

• Development of inhibitors (antibodies) against factor VIII.
• Anaphylactic or severe allergic reactions.
• Thromboembolic events (rare).
• Severe hypertension or renal impairment.

Healthcare providers should evaluate patient history and monitor for specific risks before and during Haemate therapy.

• Screen for prior inhibitors to factor VIII.
• Assess for history of allergic reactions to plasma‑derived products.
• Use caution in patients with cardiovascular disease or thrombosis risk.
• Monitor renal and hepatic function during long‑term treatment.
• Adjust dosing in pediatric or elderly patients as appropriate.
• Avoid use in patients with known hypersensitivity to any component of the formulation.

Haemate may interact with other medications that affect hemostasis or immune response.

Avoid

• Concomitant use of other factor concentrates without medical supervision.
• Administration of antifibrinolytic agents (e.g., tranexamic acid) in high doses without monitoring.

Use with caution

• Immunosuppressive drugs that may alter inhibitor development.
• Vaccines administered shortly before or after infusion.
• Concurrent anticoagulants (e.g., warfarin) may require dose adjustment.