Product image of Haldol (Haloperidol) supplied by GNH India

Haldol

Active Ingredient:
Haloperidol
Origin:
EU

Haldol (Haloperidol)

Haldol is a medication containing the active ingredient haloperidol, supplied in oral dosage forms and marketed in the European Union. It belongs to the butyrophenone class of antipsychotics and works as a dopamine D2 receptor antagonist, used under prescription for several psychiatric conditions. The drug is typically prescribed by a qualified healthcare professional and may be available in various strengths depending on the formulation and dosage regimens.

Manufacturer / TM Owner

Essential Pharma Limited

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Indications & Clinical Uses

Haldol is indicated for the management of several psychiatric disorders where dopamine dysregulation is implicated.

  • Schizophrenia (including maintenance therapy)
  • Acute psychotic episodes
  • Manic episodes associated with bipolar disorder
  • Tourette syndrome (to reduce motor and vocal tics)
  • Severe agitation in emergency settings

Side Effects

Side effects of haloperidol vary in frequency and severity.

Common

  • Drowsiness or sedation
  • Extrapyramidal symptoms (e.g., tremor, rigidity)
  • Dry mouth
  • Constipation

Serious

  • Neuroleptic malignant syndrome
  • Tardive dyskinesia
  • Cardiac arrhythmias (QT prolongation)

Precautions & Warnings

When prescribing haloperidol, clinicians consider several safety factors to minimize risk.

  • Assess patient history for cardiovascular disease
  • Monitor for signs of extrapyramidal reactions
  • Use the lowest effective dose, especially in elderly patients
  • Evaluate potential pregnancy or lactation status
  • Review liver and kidney function before dose adjustments
  • Exercise caution in patients with a history of seizures

Avoid Interactions

Haloperidol may interact with other medications, altering its effectiveness or safety profile.

Avoid

  • Other dopamine antagonists (e.g., metoclopramide)
  • Medications that prolong QT interval (e.g., certain antiarrhythmics)
  • Strong CYP3A4 inhibitors (e.g., ketoconazole)

Use with caution

  • CNS depressants such as benzodiazepines or alcohol
  • Anticholinergic agents (may mask extrapyramidal symptoms)
  • Antihypertensive drugs (potential additive hypotensive effect)

Frequently Asked Questions

Haloperidol acts as a dopamine D2 receptor antagonist, reducing dopaminergic neurotransmission in the brain.

Yes, Haldol is marketed in the EU and is available by prescription for approved psychiatric indications.

Haloperidol is one of the medications that may be prescribed to reduce motor and vocal tics in Tourette syndrome.

Common side effects include drowsiness, extrapyramidal symptoms such as tremor or rigidity, dry mouth, and constipation.

Serious reactions can include neuroleptic malignant syndrome, tardive dyskinesia, and cardiac arrhythmias like QT prolongation.

Yes, concurrent use with other dopamine antagonists (e.g., metoclopramide) should be avoided to reduce additive effects.

Haloperidol can increase the risk of QT prolongation, so it should be avoided with other QT‑prolonging drugs.

Dose adjustments may be necessary; clinicians should evaluate hepatic and renal function before modifying the regimen.

The safety of haloperidol in pregnancy has not been fully established; it should be used only if the potential benefit justifies the risk.

Regular monitoring for extrapyramidal symptoms, metabolic changes, cardiac rhythm (ECG), and overall clinical response is recommended.

Haloperidol is not considered habit‑forming, but abrupt discontinuation can lead to withdrawal or rebound psychosis.

Store at room temperature, away from moisture and heat, and keep the container tightly closed.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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