Product image of Harmonet (Ethinylestradiol, Gestodene) supplied by GNH India

Harmonet

Active Ingredient:
Ethinylestradiol, Gestodene
Origin:
EU

Harmonet (Ethinylestradiol, Gestodene)

Harmonet is a combined oral contraceptive tablet containing ethinylestradiol and gestodene. It is supplied in tablet form, marketed in the EU, and prescribed for hormonal contraception. The product provides a regulated dose of estrogen and progestogen to prevent pregnancy. Each tablet is intended for daily oral intake as part of a 21‑day active regimen followed by a hormone‑free interval. It is available only by prescription.

Manufacturer / TM Owner

Pfizer Kft.

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Indications & Clinical Uses

Harmonet is indicated for the prevention of pregnancy in women of reproductive age who choose an oral hormonal method.

  • Primary use as a combined oral contraceptive to inhibit ovulation.
  • Provides cycle control and reduces menstrual flow.
  • May be used to manage moderate acne related to androgen excess.
  • Can be prescribed for treatment of dysmenorrhea associated with ovulatory cycles.

Side Effects

Like other combined oral contraceptives, Harmonet may cause a range of side effects, most of which are mild and transient.

Common

  • Nausea or mild stomach upset.
  • Headache or migraine.
  • Breast tenderness.
  • Spotting or breakthrough bleeding.

Serious

  • Deep vein thrombosis or pulmonary embolism.
  • Stroke or myocardial infarction.
  • Severe hypertension.
  • Liver disorders such as cholestatic jaundice.

Precautions & Warnings

Before starting Harmonet, certain health considerations should be evaluated to ensure safe use.

  • History of blood clots, stroke, or heart disease.
  • Smoking, especially in women over 35 years of age.
  • Uncontrolled hypertension or diabetes.
  • Liver disease or severe gallbladder disease.
  • Migraine with aura.
  • Pregnancy or suspected pregnancy (contraindicated).

Avoid Interactions

Harmonet can interact with other medicines, affecting its efficacy or increasing risk of adverse events.

Avoid

  • Enzyme‑inducing anticonvulsants (e.g., carbamazepine, phenytoin).
  • Rifampin and other potent antibiotics (e.g., griseofulvin).
  • St. John’s wort herbal supplement.

Use with caution

  • Antifungal agents such as ketoconazole.
  • Certain HIV protease inhibitors.
  • Selective serotonin reuptake inhibitors (SSRIs).

Frequently Asked Questions

Harmonet contains the synthetic estrogen ethinylestradiol and the progestogen gestodene.

It works by suppressing the hypothalamic‑pituitary‑gonadal axis, which reduces LH and FSH release, inhibiting ovulation, and by altering cervical mucus and the endometrial lining.

No. Harmonet is a prescription‑only medication and must be prescribed by a qualified health professional.

Smoking, especially in women over 35, increases the risk of serious cardiovascular events with combined oral contraceptives and is generally discouraged.

If a tablet is missed, follow the guidance provided in the patient information leaflet or consult a healthcare professional for specific instructions.

There are no specific dietary restrictions, but it is advisable to maintain a balanced diet and limit excessive alcohol consumption.

Most antibiotics do not affect Harmonet, but enzyme‑inducing antibiotics such as rifampin may reduce its effectiveness.

Symptoms may include sudden leg pain or swelling, chest pain, shortness of breath, or coughing up blood; seek immediate medical attention if they occur.

Women who experience migraine with aura should discuss alternative contraceptive options, as combined oral contraceptives may increase stroke risk.

When started within the first five days of the menstrual cycle, Harmonet provides immediate contraceptive protection; otherwise, backup contraception is recommended for the first seven days.

Combined oral contraceptives, including Harmonet, may improve moderate acne related to androgen excess, but they are not approved solely for acne treatment.

If pregnancy is suspected, discontinue Harmonet immediately and contact a healthcare provider for appropriate prenatal care.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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