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Havrix

Active Ingredient:
Hepatitis A Virus (Inactivated ) Adsorbed On Aluminium Hydroxide Hydrated Produced On Human Diploid
Origin:
EU

Havrix (Hepatitis A Virus (Inactivated ) Adsorbed On Aluminium Hydroxide Hydrated Produced On Human Diploid)

Havrix is a prescription‑only hepatitis A vaccine that contains inactivated hepatitis A virus adsorbed onto aluminium hydroxide and is supplied as an injectable solution. The product is manufactured for the European market and is administered by intramuscular injection to stimulate active immunity against hepatitis A virus in adults and children. It belongs to the inactivated viral vaccine class and is used for prophylaxis of hepatitis A infection.

Manufacturer / TM Owner

Glaxosmithkline Biologicals S.A.

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Indications & Clinical Uses

Havrix is indicated for the prevention of hepatitis A infection in individuals who are at risk of exposure.

  • Travel to regions where hepatitis A is endemic or where outbreaks have been reported.
  • Occupational exposure for laboratory personnel handling hepatitis A virus.
  • Household contacts of persons with confirmed hepatitis A infection.
  • Patients with chronic liver disease who require additional protection.
  • Individuals seeking immunity before receiving blood products or organ transplants.

Side Effects

Following intramuscular administration, Havrix may be associated with a range of transient reactions. These events typically appear within a few days after vaccination and resolve without specific treatment. Medical evaluation is advised if they persist.

Common

  • Pain, redness or swelling at the injection site
  • Mild fever
  • Headache
  • Fatigue
  • Muscle aches
  • Nausea or gastrointestinal discomfort

Serious

  • Severe allergic reaction (anaphylaxis)
  • Guillain‑Barré syndrome (very rare)
  • High fever lasting more than 24 hours
  • Seizures (rare)
  • Neurological symptoms such as weakness or numbness

Precautions & Warnings

Healthcare providers should assess individual risk factors and medical history before administering Havrix to ensure safe use.

  • Defer vaccination in persons with known severe allergy to any vaccine component, including aluminium salts.
  • Postpone administration in individuals experiencing moderate or severe acute illness.
  • Consider delaying the vaccine in pregnant women; safety data are limited.
  • Observe patients for at least 15 minutes after injection to monitor for immediate hypersensitivity.
  • Immunocompromised patients may have a reduced antibody response; discuss alternative protection strategies.
  • Do not administer concurrently with other live vaccines; separate by at least 4 weeks.

Avoid Interactions

Havrix does not have many documented drug‑drug interactions, but certain co‑administered agents may require attention.

Avoid

  • Concurrent administration with other injectable vaccines containing aluminium adjuvants, which may increase local reactogenicity.
  • Live viral vaccines given within 4 weeks before or after Havrix, to avoid interference with immune response.

Use with caution

  • Immunosuppressive therapies (e.g., corticosteroids, chemotherapy) that could diminish vaccine efficacy.
  • Antipyretics such as acetaminophen or ibuprofen taken prophylactically, which might blunt antibody production.
  • Blood products administered shortly before or after vaccination, as they may affect seroconversion.

Frequently Asked Questions

Havrix is an inactivated hepatitis A vaccine that contains killed hepatitis A virus adsorbed onto aluminium hydroxide. When injected intramuscularly, it stimulates the immune system to produce antibodies that provide active protection against hepatitis A infection.

Havrix is recommended for individuals who are at increased risk of hepatitis A exposure, such as travelers to endemic areas, people with occupational exposure, close contacts of infected persons, and those with chronic liver disease.

The vaccine is supplied as an injectable solution and is given by intramuscular injection, typically in the deltoid muscle, by a qualified healthcare professional.

Common reactions include pain, redness or swelling at the injection site, mild fever, headache, fatigue, muscle aches, and occasional nausea. These effects are usually short‑lived.

Rare serious events may include severe allergic reactions (anaphylaxis), Guillain‑Barré syndrome, high fever lasting more than 24 hours, seizures, or neurological symptoms. Prompt medical attention is advised if such symptoms occur.

Safety data for use in pregnancy are limited; therefore, vaccination is generally deferred unless the potential benefit outweighs the potential risk, as determined by a healthcare provider.

Individuals with a known severe allergy to vaccine components, those with moderate or severe acute illness, or those who are immunocompromised should discuss vaccination timing with their clinician. Observation after injection is recommended.

Havrix has few documented drug interactions. However, concurrent use of immunosuppressive agents, prophylactic antipyretics, or recent receipt of blood products may affect the immune response and should be discussed with a provider.

Live viral vaccines should be spaced at least four weeks apart from Havrix. Co‑administration with other inactivated vaccines containing aluminium adjuvants may increase local reactions.

The vaccine provides long‑term immunity, often lasting many years, but exact duration can vary. Booster doses may be considered for continued protection in high‑risk individuals.

Havrix is available by prescription through pharmacies, travel clinics, and healthcare facilities authorized to dispense vaccines within EU member states.

Seek immediate medical care, especially if symptoms such as difficulty breathing, swelling of the face or throat, or a high fever develop. Report the event to the local pharmacovigilance authority.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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