Hebe (Ketorolac Trometamol)

Hebe is indicated for the management of ocular inflammation and discomfort in several clinical situations. The eye drops are applied directly to the affected eye, allowing localized drug delivery with minimal systemic exposure.

• Post‑operative inflammation following cataract or intraocular lens surgery.
• Acute anterior uveitis or iritis where rapid anti‑inflammatory effect is desired.
• Post‑traumatic eye irritation and swelling after corneal injury.
• Prevention of pain and redness after photorefractive keratectomy (PRK) or LASIK procedures.
• Management of allergic conjunctivitis when NSAID therapy is appropriate.

Adverse reactions to Hebe are generally mild and localized to the eye, but ocular NSAIDs can also be associated with less frequent but potentially serious ocular events that may require medical attention.

Common

• Transient eye irritation or burning sensation upon instillation, lasting seconds.
• Temporary blurred vision that clears within minutes.
• Mild conjunctival redness that improves without treatment.
• Slight increase in tear production causing a watery eye.
• Dry eye sensation that may improve with lubricating drops.
• Mild photophobia that diminishes as the medication works.

Serious

• Corneal ulceration or epithelial defect that may affect vision.
• Persistent intraocular inflammation needing additional therapy.
• Severe allergic reaction with eyelid swelling and itching.
• Elevated intraocular pressure that could lead to glaucoma if untreated.

When using Hebe, certain precautions should be observed to minimize risk and ensure appropriate therapeutic outcomes.

• Do not use if you have a known hypersensitivity to ketorolac, other NSAIDs, or any component of the formulation.
• Avoid administration in eyes with active infection unless directed by an ophthalmologist.
• Use with caution in patients with a history of corneal disease, ulceration, or delayed wound healing.
• Monitor intraocular pressure in patients at risk for glaucoma during prolonged therapy.
• Do not exceed the prescribed dosing frequency; overuse may increase the risk of ocular irritation.
• Inform your eye care professional if you are pregnant, planning pregnancy, or breastfeeding.

Ketorolac eye drops may interact with other ocular or systemic medications, influencing efficacy or safety.

Avoid

• Concurrent use with other topical NSAIDs or corticosteroid eye drops without professional guidance, as additive effects on intraocular pressure or delayed healing may occur.
• Simultaneous administration of ocular anesthetics that could mask irritation signs, potentially delaying detection of adverse reactions.

Use with caution

• Systemic NSAIDs or anticoagulants, because combined systemic exposure may increase the risk of bleeding or affect wound healing.
• Beta‑blocker eye drops, as combined therapy may influence intraocular pressure control.
• Herbal supplements such as ginkgo biloba or fish oil, which have mild antiplatelet activity and could theoretically affect ocular healing.