Product image of Helex Sr (Alprazolam) supplied by GNH India

Helex Sr

Active Ingredient:
Alprazolam
Origin:
EU

Helex Sr (Alprazolam)

Helex Sr is a prescription medication that contains the active ingredient alprazolam, a benzodiazepine class anxiolytic, supplied in oral form. It is marketed in the European Union and classified as a controlled psychotropic substance. Alprazolam works as a positive allosteric modulator of the GABA‑A receptor, enhancing inhibitory neurotransmission in the central nervous system. Helex Sr is used under medical supervision for specific anxiety‑related conditions and panic disorders.

Manufacturer / TM Owner

Krka-Farma D.O.O.

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Indications & Clinical Uses

Helex Sr is indicated for the short‑term management of certain anxiety‑related disorders under physician guidance.

  • Generalized anxiety disorder (GAD)
  • Panic disorder with or without agoraphobia
  • Situational anxiety such as performance anxiety
  • Adjunctive treatment of anxiety symptoms associated with depressive disorders
  • Short‑term relief of acute anxiety episodes

Side Effects

Common side effects of Helex Sr are generally mild and may resolve with continued use.

Common

  • Drowsiness or sedation
  • Fatigue and weakness
  • Dizziness or light‑headedness
  • Impaired coordination or balance
  • Dry mouth or blurred vision

Serious

  • Depression or suicidal thoughts
  • Severe allergic reaction (rash, swelling, difficulty breathing)
  • Respiratory depression, especially when combined with other depressants
  • Paradoxical agitation or aggression
  • Dependence, tolerance, or withdrawal symptoms upon abrupt discontinuation

Precautions & Warnings

Helex Sr should be used only as prescribed, with attention to several safety considerations.

  • Risk of physical and psychological dependence; avoid non‑medical use
  • Not recommended for patients with severe respiratory insufficiency
  • Caution in elderly patients due to increased fall and sedation risk
  • Do not discontinue abruptly; taper under medical supervision
  • Use with caution in hepatic impairment or reduced liver function
  • Discuss pregnancy, lactation, and contraceptive use with a healthcare provider

Avoid Interactions

Helex Sr can interact with other medicines, affecting its safety and effectiveness.

Avoid

  • Other central nervous system depressants such as opioids, barbiturates, and alcohol
  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, clarithromycin)
  • Monoamine oxidase inhibitors (MAOIs) taken within 14 days of Helex Sr

Use with caution

  • Central nervous system stimulants or certain antidepressants
  • CYP3A4 inducers (e.g., rifampin, carbamazepine, phenytoin)
  • Medications that lower seizure threshold

Frequently Asked Questions

Helex Sr is a prescription medication marketed in the European Union that contains the active ingredient alprazolam, a benzodiazepine used as an anxiolytic.

Alprazolam acts as a positive allosteric modulator of the GABA‑A receptor, increasing the inhibitory effect of GABA and producing a calming effect on the central nervous system.

Helex Sr is prescribed for the short‑term treatment of anxiety disorders, including generalized anxiety disorder, and for panic disorder with or without agoraphobia.

Yes, Helex Sr is classified as a controlled psychotropic substance and is available only with a prescription in the European Union.

Alcohol can increase the sedative effects of Helex Sr and may lead to excessive drowsiness or respiratory depression; it is generally advised to avoid alcohol while using this medication.

Common side effects include drowsiness, fatigue, dizziness, impaired coordination, dry mouth, and blurred vision.

Serious reactions such as severe depression, suicidal thoughts, respiratory depression, allergic reactions with swelling or difficulty breathing, and paradoxical agitation should be reported to a healthcare professional right away.

Helex Sr should not be stopped abruptly; a physician will usually recommend a gradual taper to reduce the risk of withdrawal symptoms.

Elderly patients may be more sensitive to sedation and fall risk, so lower doses and careful monitoring are recommended.

The safety of alprazolam during pregnancy and lactation is not well established; patients should discuss potential risks with their healthcare provider.

Medications that should be avoided include other central nervous system depressants (e.g., opioids, barbiturates, alcohol) and strong CYP3A4 inhibitors such as ketoconazole or clarithromycin.

CYP3A4 inducers like rifampin or carbamazepine may reduce alprazolam levels, potentially requiring dose adjustments under medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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