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Helicid

Active Ingredient:
Omeprazole Sodium
Origin:
EU

Helicid (Omeprazole Sodium)

Helicid is an intravenous solution that contains omeprazole sodium, a proton‑pump inhibitor marketed in the European Union. It is supplied in a standard concentration for hospital administration and is prescribed by healthcare professionals for the treatment and prevention of acid‑related gastrointestinal conditions. As a prescription‑only product, Helicid is used under medical supervision to reduce gastric acid secretion through irreversible inhibition of the gastric proton pump.

Manufacturer / TM Owner

Zentiva, K.S.

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Indications & Clinical Uses

Helicid is indicated for several acid‑related disorders where reduction of gastric acidity is required.

  • Treatment of gastric ulcer
  • Treatment of duodenal ulcer
  • Management of gastro‑oesophageal reflux disease (GERD)
  • Prophylaxis of NSAID‑induced ulceration
  • Treatment of Zollinger‑Ellison syndrome

Side Effects

The safety profile of Helicid reflects the typical effects observed with intravenous proton‑pump inhibitors.

Common

  • Headache
  • Diarrhea
  • Nausea
  • Abdominal pain

Serious

  • Severe allergic reaction (anaphylaxis)
  • Clostridioides difficile‑associated diarrhea
  • Elevated liver enzymes

Precautions & Warnings

When prescribing Helicid, clinicians should consider several precautionary measures to ensure safe use.

  • Assess liver function before initiating therapy.
  • Use with caution in patients with known hypersensitivity to omeprazole or other PPIs.
  • Monitor for signs of infection, especially Clostridioides difficile, during prolonged treatment.
  • Adjust therapy in patients with severe renal impairment if the formulation contains excipients cleared renally.
  • Evaluate the need for long‑term use, as chronic suppression of gastric acid may affect nutrient absorption.
  • Consider pregnancy risk; safety data are limited.

Avoid Interactions

Helicid may interact with other medicines, influencing their effectiveness or safety.

Avoid

  • Co‑administration with drugs that require an acidic gastric pH for absorption (e.g., ketoconazole, itraconazole, atazanavir).
  • Concurrent use with rilpivirine‑containing antiretroviral regimens.

Use with caution

  • Clopidogrel – reduced antiplatelet effect.
  • Warfarin – potential alteration of INR.
  • Methotrexate – increased serum levels.
  • Digoxin – possible increased concentration.

Frequently Asked Questions

Helicid contains omeprazole sodium, which irreversibly inhibits the H+/K+ ATPase (gastric proton pump) in parietal cells, leading to a marked reduction in gastric acid secretion.

Helicid is used for gastric and duodenal ulcers, gastro‑oesophageal reflux disease (GERD), prophylaxis of NSAID‑induced ulcers, and treatment of Zollinger‑Ellison syndrome.

Helicid is supplied as an intravenous solution and must be administered by a healthcare professional through a vein.

Liver function should be evaluated before starting Helicid, and patients with severe hepatic impairment may require closer monitoring.

Safety data for Helicid in pregnancy are limited; it should be used only if the potential benefit justifies the potential risk to the fetus.

Common side effects include headache, diarrhea, nausea, and abdominal pain.

Serious reactions such as anaphylaxis, Clostridioides difficile‑associated diarrhea, and significant liver enzyme elevations should be reported promptly.

Yes, Helicid may reduce the antiplatelet effect of clopidogrel; clinicians should consider alternative strategies or monitor platelet function.

Helicid should be avoided with antifungal agents that require an acidic environment for absorption, such as ketoconazole and itraconazole.

The duration of therapy should be the minimum necessary; long‑term use may increase the risk of nutrient malabsorption and infections.

Renal adjustment is generally not required for omeprazole itself, but formulation excipients may need consideration in severe renal impairment.

Yes, Helicid is indicated for prophylaxis of NSAID‑induced gastric ulcers when oral therapy is not feasible.

Published by

GNH India Pharmaceuticals Limited

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Last updated:

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