Product image of Hemangiol (Propranolol Hydrochloride) supplied by GNH India

Hemangiol

Active Ingredient:
Propranolol Hydrochloride
Origin:
EU

Hemangiol (Propranolol Hydrochloride)

Hemangiol is a prescription oral product that contains the active ingredient propranolol hydrochloride. It is marketed in the European Union and is supplied as an oral formulation, though specific tablet strength is not disclosed. As a non‑selective beta‑adrenergic receptor blocker, Hemangiol works by inhibiting β1 and β2 receptors, affecting heart rate, contractility, and angiogenic pathways in certain vascular lesions.

Manufacturer / TM Owner

Pierre Fabre Medicament

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Indications & Clinical Uses

Hemangiol is indicated for several cardiovascular and vascular conditions, based on its beta‑blocker activity. It is commonly prescribed for:

  • Infantile hemangioma, to reduce lesion growth and promote regression
  • Hypertension, as part of blood pressure management
  • Angina pectoris, to decrease myocardial oxygen demand
  • Cardiac arrhythmias, for rate control in supraventricular tachycardia
  • Off‑label use in migraine prophylaxis under specialist supervision

Side Effects

Side effects of Hemangiol vary in frequency and severity. Patients should be aware of both common and serious reactions.

Common

  • Fatigue or tiredness
  • Dizziness, especially when standing quickly
  • Cold extremities or reduced peripheral circulation
  • Gastrointestinal upset such as nausea or abdominal discomfort
  • Sleep disturbances or vivid dreams

Serious

  • Marked bradycardia or heart block
  • Severe hypotension
  • Bronchospasm in patients with asthma
  • Hypoglycemia unawareness in diabetic patients
  • Mood changes or depression

Precautions & Warnings

Before starting Hemangiol, certain precautions should be considered to ensure safe use.

  • Assess cardiovascular status, especially for bradycardia or heart block
  • Evaluate respiratory conditions, as asthma may worsen
  • Monitor blood glucose in diabetic patients, as beta‑blockade can mask hypoglycemia symptoms
  • Use cautiously in patients with severe peripheral vascular disease
  • Review liver and kidney function periodically
  • Discuss pregnancy and lactation status with a healthcare professional, as safety data are limited

Avoid Interactions

Hemangiol can interact with several drug classes; some combinations should be avoided while others require careful monitoring.

Avoid

  • Other beta‑blockers or calcium‑channel blockers that may cause additive cardiac depression
  • Non‑selective alpha agonists such as clonidine, which can exacerbate hypotension
  • Certain anti‑arrhythmic agents (e.g., amiodarone) that increase plasma propranolol levels

Use with caution

  • Antidiabetic medications, due to potential masking of hypoglycemia
  • NSAIDs, which may reduce antihypertensive efficacy
  • Antidepressants (e.g., SSRIs) that can affect heart rate
  • Inhaled bronchodilators, as beta‑blockade may diminish their effect

Frequently Asked Questions

Hemangiol works by non‑selectively blocking β1 and β2 adrenergic receptors, which reduces heart rate, myocardial contractility, and angiogenic signaling in hemangioma tissue.

Hemangiol is commonly prescribed for infantile hemangioma, hypertension, angina pectoris, and certain cardiac arrhythmias.

Hemangiol may exacerbate bronchospasm in asthmatic patients; it should be used with caution and only under close medical supervision.

Common side effects include fatigue, dizziness, cold extremities, gastrointestinal upset, and sleep disturbances.

Serious reactions such as marked bradycardia, severe hypotension, bronchospasm, hypoglycemia unawareness, or mood changes should prompt urgent medical evaluation.

Because propranolol can affect heart rate and blood pressure, physicians often advise stopping Hemangiol before major surgery, but the decision should be individualized.

Beta‑blockade can mask typical hypoglycemia symptoms, so diabetic patients using Hemangiol should monitor glucose levels more frequently.

The safety of Hemangiol in pregnancy has not been established; pregnant or breastfeeding individuals should discuss risks with their healthcare provider.

NSAIDs may reduce the antihypertensive effect of Hemangiol; they can be used together but blood pressure should be monitored.

Periodic assessment of heart rate, blood pressure, liver and kidney function, and blood glucose (in diabetics) is recommended.

Dose adjustments may be necessary for patients with significant renal dysfunction; dosing decisions should be made by a qualified clinician.

Hemangiol should be stored at room temperature, protected from moisture and light, and kept out of reach of children.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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