Product image of Heminevrin (Clomethiazole) supplied by GNH India

Heminevrin

Active Ingredient:
Clomethiazole
Origin:
EU

Heminevrin (Clomethiazole)

Clomethiazole, the active ingredient in Heminevrin, is a sedative‑hypnotic presented as an oral formulation for oral use. It is employed in the management of alcohol withdrawal, provides sedation, and may be used to treat severe insomnia in adult patients.

GNH India supplies Heminevrin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable global logistics for regulated medicines, including temperature‑controlled shipping where required and comprehensive regulatory documentation.

Manufacturer / TM Owner

Neon Healthcare Limited

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Indications & Clinical Uses

Clomethiazole is used in clinical practice to manage conditions related to central nervous system depression and alcohol dependence.

  • Alcohol withdrawal syndrome: reduces withdrawal symptoms and prevents progression to severe complications such as seizures.
  • Sedation: provides controlled sedation for pre‑procedural or intensive care settings.
  • Insomnia: assists in short‑term management of severe insomnia when other therapies are unsuitable.

How It Works

  • Clomethiazole acts as a positive allosteric modulator of the GABA‑A receptor complex. By binding to a distinct site on the receptor, it enhances the inhibitory effect of GABA, increasing chloride ion influx into neurons. This potentiation leads to heightened neuronal hyperpolarisation, producing sedative‑hypnotic effects comparable to barbiturates and facilitating control of CNS hyper‑excitability during alcohol withdrawal.

Side Effects

Clomethiazole may cause a range of adverse reactions, which are grouped by frequency and severity.

Common Side Effects

  • Drowsiness: feeling of excessive sleepiness.
  • Dizziness: light‑headed sensation.
  • Headache: mild to moderate pain.
  • Nausea: upset stomach or urge to vomit.
  • Dry mouth: reduced salivation.
  • Hypotension: lowered blood pressure.

Serious or Rare Side Effects

  • Respiratory depression: slowed or shallow breathing.
  • Severe hypotension: marked drop in blood pressure.
  • Allergic reactions: rash, itching, swelling, or anaphylaxis.
  • Hepatic dysfunction: elevated liver enzymes or jaundice.
  • Seizures: occurrence of convulsive episodes.
  • Cardiac arrhythmia: irregular heart rhythm.

Precautions & Warnings

When prescribing clomethiazole, clinicians should observe several safety considerations.

  • Liver function: assess hepatic status before initiation and monitor during therapy.
  • Respiratory status: observe patients with compromised breathing, especially when combined with other depressants.
  • Concomitant CNS depressants: avoid or use with caution when taken with alcohol, benzodiazepines, opioids, or antihistamines.
  • Discontinuation: do not stop abruptly; taper the dose to minimise withdrawal effects.
  • Renal impairment: adjust dosing in severe renal dysfunction if applicable.
  • Store below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Clomethiazole can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Alcohol: additive CNS depression may lead to profound sedation or respiratory failure.
  • Benzodiazepines and barbiturates: combined effect can cause severe respiratory depression and excessive sedation.
  • Opioids: risk of profound respiratory compromise and hypotension.

Moderate Interactions (Monitor Closely)

  • Antidepressants (especially SSRIs): may increase sedation or affect serotonin pathways.
  • Antihypertensive agents: additive hypotensive effect may require blood pressure monitoring.
  • Anticholinergic drugs: may exacerbate dry mouth and urinary retention.

Frequently Asked Questions

Heminevrin contains clomethiazole and is prescribed to manage alcohol withdrawal syndrome, to provide short‑term sedation in clinical settings, and to treat severe insomnia when other options are not appropriate. It works by calming excessive central nervous system activity associated with these conditions.

Clomethiazole enhances the activity of the neurotransmitter GABA at the GABA‑A receptor. By binding to an allosteric site, it increases the flow of chloride ions into neurons, leading to greater neuronal inhibition. This results in sedative‑hypnotic effects that help control withdrawal symptoms and induce sleep.

The dosage of Heminevrin is individualized by the prescribing clinician based on the patient’s condition, age, weight, liver function and other medications. The prescriber determines the appropriate strength, frequency and duration of therapy, and patients should follow the prescribed regimen exactly.

Safety data for clomethiazole in pregnancy and lactation are limited. Because the drug crosses the placenta and may be excreted in breast milk, it should only be used when the potential benefit justifies the possible risk to the fetus or infant. Consultation with a healthcare professional is essential.

To request Heminevrin, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any temperature‑controlled requirements) and necessary import documentation.

Clomethiazole shares a similar sedative‑hypnotic profile with benzodiazepines such as diazepam, but it binds to a different site on the GABA‑A receptor and may have a shorter half‑life. It is often chosen when rapid onset of sedation is needed, though careful monitoring is required due to its additive depressant effects.

Heminevrin should be stored below 25 °C in its original container, protected from moisture and direct sunlight. Keep the product out of reach of children and avoid exposing it to extreme temperatures. No special refrigeration is required for the oral formulation.

Heminevrin is taken orally, usually with a glass of water. The tablet or capsule is swallowed whole and should be taken exactly as prescribed. Patients should not crush, chew, or split the dosage form unless directed by a healthcare professional.

The most serious adverse events include respiratory depression, severe hypotension, allergic reactions such as anaphylaxis, hepatic dysfunction, seizures and cardiac arrhythmias. Prompt medical attention is required if any of these symptoms develop, especially when the drug is used with other central nervous system depressants.

Heminevrin is contraindicated in patients with known hypersensitivity to clomethiazole, severe hepatic impairment, or those who are currently intoxicated with alcohol or other CNS depressants. Caution is also advised for individuals with uncontrolled respiratory disorders, severe renal dysfunction, or a history of severe cardiac arrhythmias.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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