Hemosol B0 (Calcium, Lactic Acid, Magnesium, Sodium, Chloride Ion, Hydrogen Carbonate)

Hemosol B0 is indicated for several clinical situations where electrolyte and acid‑base control are required.

• Hemodialysis procedures to replace lost electrolytes and maintain buffer capacity.
• Acute renal failure when intravenous electrolyte supplementation is needed.
• Peri‑operative fluid management in patients undergoing major surgery with renal risk.
• Treatment of metabolic acidosis associated with renal insufficiency.
• Electrolyte replacement in patients receiving large-volume parenteral nutrition.
• Support of patients with chronic kidney disease during intermittent dialysis sessions.

Adverse reactions to Hemosol B0 are generally related to its electrolyte composition and infusion characteristics.

Common

• Mild nausea or vomiting during infusion.
• Transient headache or dizziness.
• Local irritation at the injection site, such as erythema or mild pain.
• Temporary changes in serum calcium or magnesium levels that resolve without intervention.
• Elevated serum chloride resulting in mild metabolic acidosis.
• Minor fluctuations in sodium levels causing mild thirst.

Serious

• Severe hypercalcemia or hypermagnesemia leading to cardiac arrhythmias.
• Acute metabolic alkalosis with significant pH shift.
• Anaphylactic or severe hypersensitivity reactions, including bronchospasm.
• Rapid fluid overload causing pulmonary edema.
• Life‑threatening hyperkalemia if solution is mixed incorrectly.
• Severe electrolyte imbalance resulting in seizures or coma.

When prescribing or administering Hemosol B0, clinicians should observe several precautionary measures to ensure patient safety.

• Verify patient electrolyte baseline values before initiation.
• Adjust infusion rate according to individual fluid status and cardiac function.
• Avoid use in patients with known hypersensitivity to any component of the solution.
• Monitor serum calcium, magnesium, and acid‑base status regularly during therapy.
• Use caution in patients with congestive heart failure or pulmonary edema risk.
• Do not exceed recommended volume limits in pediatric patients.
• Ensure compatibility with other intravenous solutions; avoid mixing with calcium‑containing drugs unless specifically indicated.

Hemosol B0 may interact with other medications or solutions administered concurrently.

Avoid

• Concurrent infusion of calcium‑containing medications that could cause precipitation.
• Co‑administration with potassium‑sparing diuretics that may exacerbate hyperkalemia.
• Mixing with blood products that contain citrate, which can alter calcium balance.

Use with caution

• Concurrent use of loop diuretics, requiring close monitoring of electrolytes.
• Administration alongside bicarbonate‑containing solutions, which may increase risk of metabolic alkalosis.
• Use with vasopressors, as rapid shifts in electrolytes can affect hemodynamic stability.