Hemosol B0 (Calcium, Lactic Acid, Magnesium, Sodium, Chloride Ion, Hydrogen Carbonate)

HemoSol B0 is used in clinical practice to address electrolyte and acid‑base disturbances when intravenous therapy is required.

• Replacement of calcium and magnesium losses during surgery or trauma.
• Correction of metabolic acidosis by providing bicarbonate precursors.
• Support of plasma electrolyte balance in patients receiving large-volume fluid resuscitation.
• Adjunctive therapy for patients with renal replacement therapy or dialysis.
• Management of hypochloremia or hyponatremia in critical care settings.

Adverse reactions to HemoSol B0 are generally infrequent, but they may occur with any intravenous solution.

Common

• Mild infusion site irritation or erythema.
• Transient nausea or vomiting.
• Slight increase in serum calcium or magnesium levels without clinical significance.
• Temporary feeling of warmth or flushing during administration.
• Mild headache or dizziness during infusion.

Serious

• Hypercalcemia or hypermagnesemia leading to cardiac arrhythmia.
• Severe metabolic alkalosis from excess bicarbonate.
• Anaphylactic or severe allergic reaction manifesting as hypotension, bronchospasm, or urticaria.
• Pulmonary edema due to rapid infusion of large volumes.
• Acute renal impairment associated with electrolyte imbalance.

When using HemoSol B0, clinicians should observe specific precautions to minimize risks and ensure appropriate patient monitoring.

• Assess baseline serum electrolytes, especially calcium, magnesium, sodium, and chloride, before initiation.
• Adjust infusion rate according to patient volume status and cardiac function.
• Avoid rapid administration in patients at risk for fluid overload or pulmonary edema.
• Monitor arterial blood gases and acid‑base status during therapy.
• Use caution in patients with renal insufficiency or on dialysis.
• Discontinue if signs of hypercalcemia, hypermagnesemia, or severe alkalosis develop.
• Document any adverse reactions in the patient record.

HemoSol B0 may interact with other intravenous medications or solutions, requiring careful coordination of therapy.

Avoid

• Concurrent infusion with calcium‑binding agents such as bisphosphonates, which can reduce calcium availability.
• Simultaneous administration of high‑dose sodium bicarbonate, which may exacerbate metabolic alkalosis.

Use with caution

• Co‑administration with loop diuretics, as they can amplify electrolyte shifts.
• Use alongside cardiotoxic drugs (e.g., digoxin) when serum calcium is elevated.
• Combination with other magnesium‑containing solutions, to prevent hypermagnesemia.
• Overlap with blood products that contain citrate, which may affect calcium levels.