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Hemosol B0

Active Ingredient:
Calcium, Lactic Acid, Magnesium, Sodium, Chloride Ion, Hydrogen Carbonate
Origin:
EU

Hemosol B0 (Calcium, Lactic Acid, Magnesium, Sodium, Chloride Ion, Hydrogen Carbonate)

Hemosol B0 is a dialysis solution containing calcium, lactic acid, magnesium, sodium, chloride ion, and hydrogen carbonate. It is supplied as a sterile solution for injection intended for use during haemodialysis. The product is manufactured for the European market and is prescribed by healthcare professionals for renal replacement therapy.

Manufacturer / TM Owner

Vantive Belgium

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Indications & Clinical Uses

Hemosol B0 is employed in clinical settings to support patients undergoing renal replacement procedures. It helps maintain electrolyte balance and correct acid‑base disturbances during treatment.

  • Hemodialysis for patients with acute or chronic kidney failure
  • Acute renal failure requiring temporary renal support
  • Chronic kidney disease patients on maintenance dialysis
  • Intra‑dialytic correction of electrolyte imbalances
  • Bicarbonate buffering during high‑flux dialysis

Side Effects

Side effects reported with Hemosol B0 are generally related to the composition of the solution and the dialysis procedure.

Common

  • Mild hypotension during dialysis
  • Transient nausea or vomiting
  • Mild muscle cramps or tingling sensations
  • Temporary changes in blood pressure
  • Mild headache
  • Slight increase in serum calcium or magnesium levels

Serious

  • Severe electrolyte disturbances (hypercalcemia, hypermagnesemia)
  • Acute metabolic alkalosis
  • Anaphylactic or severe allergic reactions
  • Cardiac arrhythmias linked to electrolyte shifts
  • Hemolysis due to solution incompatibility

Precautions & Warnings

When using Hemosol B0, clinicians should consider patient-specific factors and monitor relevant parameters throughout treatment.

  • Verify patient electrolyte and acid‑base status before initiation
  • Adjust dialysate composition for patients with known electrolyte disorders
  • Monitor blood pressure and volume status during the session
  • Use caution in patients with cardiac conduction abnormalities
  • Avoid rapid changes in bicarbonate concentration to prevent alkalosis
  • Ensure compatibility with the dialysis machine and other solutions
  • Document any adverse reactions promptly

Avoid Interactions

Hemosol B0 may interact with medications or conditions that affect electrolyte balance or acid‑base status.

Avoid

  • Concurrent use of high‑dose calcium or magnesium supplements without adjustment
  • Administration of strong acidifying agents that could counteract bicarbonate buffering
  • Use with drugs that significantly prolong QT interval in the presence of electrolyte shifts

Use with caution

  • Loop diuretics that alter calcium and magnesium excretion
  • ACE inhibitors or ARBs that affect potassium and sodium balance
  • Anticoagulants, as dialysis may influence bleeding risk
  • Beta‑blockers, due to potential additive hypotensive effects

Frequently Asked Questions

Hemosol B0 provides essential electrolytes and a bicarbonate buffer to help correct acid‑base and electrolyte imbalances during haemodialysis.

The solution contains calcium, magnesium, sodium, chloride ion, and hydrogen carbonate, along with lactic acid as a metabolic substrate.

Yes, it is indicated for patients with acute renal failure as well as those with chronic kidney disease who require regular haemodialysis.

It is supplied as a sterile solution for injection and is introduced into the dialysis circuit as the dialysate during haemodialysis.

Clinicians should monitor blood pressure, serum electrolytes, acid‑base status, and any signs of adverse reactions throughout the dialysis session.

Serious side effects can include severe electrolyte disturbances, metabolic alkalosis, cardiac arrhythmias, and rare allergic reactions.

Calcium supplementation may need adjustment, as the solution already provides calcium; clinicians should evaluate total calcium intake.

Compatibility should be confirmed with the specific dialysis equipment manufacturer, as solution composition may affect machine settings.

Patients with known conduction abnormalities should be closely monitored for electrolyte‑related arrhythmias during treatment.

Use in pediatric patients should follow local guidelines and be based on individualized dosing and monitoring by a pediatric nephrologist.

Lactic acid serves as a metabolic substrate that can be metabolized to bicarbonate, supporting the buffer capacity of the solution.

Hypotension should be managed according to standard dialysis protocols, which may include adjusting ultrafiltration rates or administering fluids.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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