Hemosol B0 (Calcium, Lactic Acid, Magnesium, Sodium, Chloride Ion, Hydrogen Carbonate)

Hemosol B0 is indicated for use during hemodialysis and other forms of renal replacement therapy where precise electrolyte and acid‑base management is required.

• Provides calcium, magnesium, sodium, and bicarbonate to maintain plasma electrolyte concentrations during dialysis.
• Helps correct metabolic acidosis by delivering bicarbonate and lactic acid buffers.
• Supports fluid balance by contributing isotonic sodium chloride.
• Can be used as a priming or replacement solution in dialysis circuits.
• May be employed in continuous renal replacement therapy (CRRT) when a balanced electrolyte composition is needed.

Adverse reactions to Hemosol B0 are generally infrequent, but they may occur during or after administration.

Common

• Mild transient hypotension
• Localized irritation at the infusion site
• Slight increase in serum calcium or magnesium levels
• Nausea or mild headache

Serious

• Severe hypercalcemia or hypermagnesemia
• Acute metabolic alkalosis
• Anaphylactic or severe hypersensitivity reaction

When prescribing or administering Hemosol B0, clinicians should observe several precautionary measures to ensure patient safety.

• Verify baseline electrolyte and acid‑base status before infusion.
• Adjust dose in patients with known hypercalcemia, hypermagnesemia, or severe metabolic alkalosis.
• Use caution in patients with cardiac arrhythmias or compromised cardiac function.
• Monitor blood pressure and signs of fluid overload during treatment.
• Avoid rapid infusion rates that could cause sudden shifts in plasma electrolytes.
• Assess for any history of hypersensitivity to solution components.

Hemosol B0 may interact with other medications or solutions that affect electrolyte balance or acid‑base status.

Avoid

• Concurrent infusion of high‑concentration calcium or magnesium solutions.
• Administration with other bicarbonate‑rich fluids that could cause alkalosis.
• Use together with loop diuretics that markedly alter sodium and chloride levels.

Use with caution

• Co‑administration of ACE inhibitors or ARBs, which can affect potassium and renal handling.
• Concurrent use of digoxin, as electrolyte shifts may modify its therapeutic window.
• Combination with blood products that contain citrate, influencing calcium levels.