Hemosol B0 (Calcium, Lactic Acid, Magnesium, Sodium, Chloride Ion, Hydrogen Carbonate)

Hemosol B0 is indicated for specific clinical situations where precise electrolyte control is required.

• Replacement of electrolytes during haemodialysis procedures.
• Intravenous fluid therapy for patients with acute or chronic electrolyte disturbances.
• Support of acid‑base balance in patients receiving large-volume resuscitation.
• Adjunctive use in peri‑operative settings where rapid electrolyte correction is needed.
• Management of hypocalcemia or hypomagnesemia in conjunction with other prescribed therapies.
• Provision of a balanced electrolyte composition for patients undergoing continuous renal replacement therapy (CRRT).

The safety profile of Hemosol B0 reflects the electrolyte composition of the solution; adverse events are generally related to the infusion process or electrolyte shifts.

Common

• Mild transient nausea or vomiting.
• Localized infusion site discomfort or erythema.
• Temporary headache.
• Mild hypotension during rapid administration.

Serious

• Severe hypercalcemia or hypermagnesemia.
• Cardiac arrhythmias associated with electrolyte imbalance.
• Pulmonary edema from fluid overload.
• Anaphylactic or severe hypersensitivity reactions.

When prescribing Hemosol B0, clinicians should evaluate patient-specific factors and monitor relevant parameters to minimize risks.

• Assess baseline serum electrolytes, especially calcium, magnesium, and sodium, before initiation.
• Adjust infusion rate in patients with compromised cardiac function or fluid overload risk.
• Use caution in pregnant or lactating women; safety data are limited.
• Monitor acid‑base status regularly during prolonged therapy.
• Avoid concurrent administration with other high‑concentration electrolyte solutions without appropriate adjustments.
• Consider renal function; dose modifications may be required in severe impairment.
• Document any allergic reactions to solution components.

Hemosol B0 may interact with other medications that influence electrolyte balance or fluid status.

Avoid

• Concurrent infusion of calcium‑containing medications without dose adjustment.
• High‑dose magnesium supplements or antacids that could precipitate hypermagnesemia.
• Sodium bicarbonate solutions administered simultaneously, which may cause abrupt pH shifts.

Use with caution

• Loop diuretics, which can exacerbate electrolyte losses.
• ACE inhibitors or ARBs, which may affect potassium and sodium homeostasis.
• Blood products containing potassium, requiring careful monitoring.
• Vasopressors, as rapid fluid shifts can influence hemodynamic response.