Hemosol B0 (Calcium, Lactic Acid, Magnesium, Sodium, Chloride Ion, Hydrogen Carbonate)

Hemosol B0 is formulated to provide essential electrolytes and buffering capacity during renal replacement therapy and fluid management.

• Dialysate for haemodialysis procedures.
• Intravenous electrolyte replacement in patients with deficits.
• Maintenance of fluid and electrolyte balance during major surgery.
• Support for patients with metabolic acidosis.
• Adjunct therapy in intensive care units for volume resuscitation.
• Use in pediatric dialysis when appropriately diluted.

Adverse reactions to Hemosol B0 are generally related to its electrolyte composition and infusion characteristics.

Common

• Mild infusion site irritation or erythema.
• Transient nausea or vomiting.
• Mild headache.
• Temporary changes in serum calcium or magnesium levels.
• Mild hypotension related to rapid infusion.

Serious

• Severe hyperkalemia or hypocalcemia if dosing errors occur.
• Acute pulmonary edema from fluid overload.
• Anaphylactic or severe allergic reaction to solution components.
• Metabolic alkalosis from excessive bicarbonate load.
• Cardiac arrhythmias secondary to electrolyte imbalance.

When using Hemosol B0, clinicians should consider patient-specific factors and monitor relevant parameters.

• Verify electrolyte levels before and during therapy to avoid imbalances.
• Adjust infusion rates in patients with compromised cardiac function.
• Use caution in patients with liver disease due to altered lactate metabolism.
• Monitor acid‑base status, especially in those prone to metabolic alkalosis.
• Ensure compatibility with other intravenous solutions and lines.
• Document any allergic reactions to solution constituents.
• Follow institutional protocols for dialysate composition adjustments.

Hemosol B0 may interact with other medications or solutions that affect electrolyte or acid‑base balance.

Avoid

• Concurrent administration of high‑dose calcium channel blockers that may exacerbate hypercalcemia.
• Use with potassium‑sparing diuretics without electrolyte monitoring.
• Mixing with solutions containing high concentrations of chloride that could precipitate.

Use with caution

• Concurrent intravenous bicarbonate therapy.
• Loop diuretics that alter sodium and magnesium excretion.
• Anticoagulants used during haemodialysis, requiring careful monitoring of volume status.
• Medications that affect lactate metabolism, such as metformin.
• Blood products that may alter ion concentrations.