Hepan (Heparin Sodium, Dexpanthenol)

Hepan is indicated for topical use in a variety of dermatological situations where its combined anticoagulant and barrier‑repair properties may be beneficial.

• Minor cuts, abrasions, and superficial wounds to support healing.
• Small bruises or contusions where reduced clot formation may aid resolution.
• Irritated or inflamed skin areas, such as mild dermatitis, to improve barrier function.
• Post‑procedure skin care (e.g., after minor dermatologic procedures) to minimize localized swelling.
• Dry or cracked skin where dexpanthenol can enhance moisture retention.

Topical application of Hepan may be associated with local skin reactions; systemic effects are uncommon due to limited absorption.

Common

• Mild erythema or redness at the application site.
• Transient itching or pruritus.
• Slight burning or stinging sensation.
• Minor skin dryness.
• Mild scaling.

Serious

• Allergic contact dermatitis with swelling or vesicle formation.
• Unexpected bruising or prolonged bleeding at the site.
• Severe skin irritation or ulceration.
• Systemic anticoagulant effect leading to abnormal bleeding (very rare).
• Hypersensitivity reaction with widespread rash.

When using Hepan, certain precautions should be observed to ensure safe and effective application.

• Do not apply to broken skin with deep wounds or large open lesions.
• Avoid use on mucous membranes, eyes, or genital areas.
• Discontinue use if signs of allergic reaction develop.
• Keep the product out of reach of children; accidental ingestion may cause systemic anticoagulant effects.
• Consult a healthcare professional before use in patients receiving systemic anticoagulant therapy.
• Do not use on infected skin without medical advice.
• Store at room temperature, protected from light and moisture.

Hepan may interact with other topical agents or systemic medications that affect coagulation or skin integrity.

Avoid

• Concurrent application of other topical anticoagulants or heparin‑containing products.
• Use with strong irritant or drying agents (e.g., high‑strength corticosteroids) on the same area.

Use with caution

• Systemic anticoagulant therapy (e.g., warfarin, direct oral anticoagulants) – monitor for increased bleeding.
• Topical antibiotics or antiseptics – assess for combined irritation.
• Dermatologic procedures (e.g., laser, microdermabrasion) – apply after wound closure.
• Use in patients with known heparin allergy – consider alternative.