Heparin Collirio (Heparin Sodium)

• Heparin Collirio acts on the coagulation cascade to manage ocular inflammation and fibrin formation after surgical procedures.
• Post‑operative ocular inflammation: reduces inflammatory response and fibrin buildup following eye surgery.
• Ocular surface inflammation: alleviates irritation and swelling of the cornea and conjunctiva.
• Prevention of fibrin formation after eye surgery: inhibits clot formation within the anterior chamber, supporting clearer postoperative recovery.

• Heparin Sodium binds to antithrombin III, enhancing its inhibitory activity against thrombin (factor IIa) and factor Xa. This accelerated inhibition prevents conversion of fibrinogen to fibrin, thereby limiting clot formation on ocular tissues. The localized ocular application results in reduced fibrin deposition and attenuation of inflammatory mediators within the eye, contributing to decreased postoperative inflammation.

Adverse reactions to Heparin Collirio are generally localized to the eye.

Common Side Effects

• Stinging or burning sensation upon instillation.
• Transient blurred vision.
• Mild conjunctival hyperemia.
• Increased tearing.
• Temporary foreign‑body sensation.
• Mild eyelid edema.

Serious or Rare Side Effects

• Allergic reaction such as angioedema or anaphylaxis.
• Severe ocular inflammation or keratitis.
• Corneal ulceration.
• Significant increase in intra‑ocular pressure.
• Vision loss unrelated to the underlying condition.
• Persistent ocular pain.

• Careful consideration is required before using Heparin Collirio.
• Allergy assessment: avoid if known hypersensitivity to heparin or any excipients.
• Eye infection: do not use on an eye with active infection without physician guidance.
• Contact lens wear: remove lenses before instillation and wait before reinserting.
• Systemic anticoagulation: monitor for systemic effects in patients receiving systemic heparin.
• Pregnancy and lactation: use only if the potential benefit justifies the potential risk.
• Store at room temperature: keep in the original container, protect from light and moisture.

Heparin Collirio may interact with other ocular or systemic agents.

Major Interactions (Avoid)

• Systemic heparin therapy: concurrent use may increase the risk of bleeding.
• Other ocular anticoagulant drops: additive anticoagulant effect can heighten bleeding risk.

Moderate Interactions (Monitor Closely)

• Topical corticosteroids: may mask signs of infection.
• Non‑steroidal anti‑inflammatory eye drops: monitor for increased ocular irritation.
• Preservative‑containing contact lens solutions: may exacerbate local irritation.