Heparine Leo (Heparin Sodium)

Heparine Leo is indicated for several antithrombotic purposes in clinical practice.

• Prevention and treatment of thromboembolic disorders such as pulmonary embolism and arterial thrombosis.
• Management of acute coronary syndrome, including unstable angina and myocardial infarction.
• Prophylaxis of deep vein thrombosis (DVT) in surgical or immobilized patients.
• Use during cardiac surgery or interventional procedures requiring anticoagulation.
• Adjunct therapy in patients with high risk of clot formation.

Heparine Leo may cause a range of side effects, varying in frequency and severity.

Common

• Minor bleeding at injection sites.
• Bruising or hematoma formation.
• Nausea or mild gastrointestinal discomfort.
• Transient elevation of liver enzymes.
• Mild thrombocytopenia (low platelet count).

Serious

• Major hemorrhage, including internal bleeding.
• Heparin-induced thrombocytopenia (HIT) with paradoxical clotting.
• Severe allergic reactions such as anaphylaxis.
• Spontaneous spinal or epidural hematoma.
• Acute renal impairment associated with bleeding complications.

Before initiating Heparine Leo, several safety considerations should be reviewed.

• Assess patient’s bleeding risk, including history of ulcers, recent surgery, or trauma.
• Monitor coagulation parameters (e.g., activated partial thromboplastin time) regularly.
• Use with caution in patients with renal or hepatic impairment.
• Evaluate pregnancy status; benefits must outweigh potential risks.
• Discontinue or adjust dose prior to invasive procedures.
• Educate patients on signs of abnormal bleeding and when to seek medical attention.

Heparine Leo can interact with various medications, influencing its anticoagulant effect.

Avoid

• Concurrent use of other anticoagulants (e.g., warfarin, direct oral anticoagulants).
• Thrombolytic agents such as alteplase or streptokinase.
• Antiplatelet drugs (e.g., clopidogrel, ticagrelor) in high‑dose regimens.

Use with caution

• Non‑steroidal anti‑inflammatory drugs (NSAIDs) and aspirin.
• Selective serotonin reuptake inhibitors (SSRIs) and other serotonergic agents.
• ACE inhibitors and angiotensin receptor blockers that may increase bleeding risk.
• Certain antibiotics (e.g., quinolones) that can affect platelet function.