Product image of Heparine Natrium B. Braun (Heparin Sodium) supplied by GNH India

Heparine Natrium B. Braun

Active Ingredient:
Heparin Sodium
Origin:
EU

Heparine Natrium B. Braun (Heparin Sodium)

Heparine Natrium B. Braun is a pharmaceutical product that contains the active ingredient heparin sodium. It is supplied as an injectable solution for intravenous administration, with the specific strength not disclosed in the available data. Classified as an anticoagulant and antithrombotic, this prescription‑only medication is marketed in the European Union and is used under medical supervision to manage clot‑related conditions.

Manufacturer / TM Owner

B.Braun Melsungen Ag

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Indications & Clinical Uses

Heparine Natrium B. Braun is indicated for several clinical situations where anticoagulation is required. It is commonly employed in the prevention and treatment of venous thromboembolic events.

  • Prevention of venous thromboembolism in postoperative or immobilized patients
  • Treatment of acute deep vein thrombosis (DVT)
  • Management of pulmonary embolism (PE)
  • Anticoagulation during cardiac surgery, including cardiopulmonary bypass
  • Anticoagulation for patients undergoing hemodialysis or other extracorporeal circuits

Side Effects

Heparine Natrium B. Braun may cause a range of adverse reactions, most of which are related to its anticoagulant activity.

Common

  • Minor bleeding at injection site
  • Hematuria (blood in urine)
  • Epistaxis (nosebleeds)
  • Gastrointestinal irritation or mild abdominal discomfort
  • Elevated liver enzymes (transient)

Serious

  • Major hemorrhage (intracranial, gastrointestinal, or surgical site)
  • Heparin‑induced thrombocytopenia (HIT)
  • Allergic reactions including anaphylaxis
  • Spontaneous spinal or epidural hematoma

Precautions & Warnings

Before initiating therapy with Heparine Natrium B. Braun, clinicians should evaluate patient‑specific risk factors and monitor relevant parameters.

  • Assess baseline coagulation status (aPTT, PT/INR) and platelet count
  • Review history of bleeding disorders, recent surgery, or trauma
  • Use caution in patients with renal or hepatic impairment
  • Avoid use in individuals with known hypersensitivity to heparin or pork products
  • Monitor for signs of heparin‑induced thrombocytopenia during treatment
  • Adjust dose or discontinue if uncontrolled bleeding occurs

Avoid Interactions

Heparine Natrium B. Braun can interact with other agents that affect hemostasis or platelet function.

Avoid

  • Concurrent use of other anticoagulants (e.g., warfarin, direct oral anticoagulants) without close monitoring
  • Thrombolytic agents (e.g., alteplase, streptokinase)
  • High‑dose aspirin or non‑steroidal anti‑inflammatory drugs (NSAIDs) that increase bleeding risk

Use with caution

  • Antiplatelet drugs such as clopidogrel or dipyridamole
  • Selective serotonin reuptake inhibitors (SSRIs) and other serotonergic agents
  • Glycoprotein IIb/IIIa inhibitors
  • Certain antibiotics (e.g., cefotetan) that may potentiate anticoagulant effect

Frequently Asked Questions

Heparine Natrium B. Braun contains heparin sodium, which potentiates antithrombin III. This enhances inhibition of thrombin (factor IIa) and factor Xa, reducing clot formation.

It is commonly prescribed for prevention of venous thromboembolism, treatment of acute deep vein thrombosis, management of pulmonary embolism, and anticoagulation during cardiac surgery or dialysis.

The product is administered intravenously as an injectable solution under the supervision of a healthcare professional.

Activated partial thromboplastin time (aPTT) is the primary test for monitoring anticoagulant effect; platelet counts are also checked to detect heparin‑induced thrombocytopenia.

No. Patients with known hypersensitivity to heparin or pork‑derived products should not receive Heparine Natrium B. Braun.

Serious bleeding may present as unexplained bruising, blood in urine or stool, vomiting blood, severe headache, or neurological changes suggesting intracranial hemorrhage.

The pregnancy safety category is not specified; clinicians must weigh potential benefits against risks and follow local guidelines when considering use in pregnant patients.

If HIT is suspected, heparin therapy should be stopped immediately and an alternative non‑heparin anticoagulant should be considered.

There are no specific dietary restrictions, but patients should avoid foods or supplements that may increase bleeding risk, such as high‑dose vitamin K or herbal products with anticoagulant properties.

Concurrent use of aspirin can increase the risk of bleeding; clinicians should monitor the patient closely or adjust therapy as appropriate.

The product should be stored according to the manufacturer’s label, typically at controlled room temperature away from light and moisture.

Dose adjustments or increased monitoring may be necessary in patients with significant renal dysfunction, as clearance of heparin can be affected.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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