Hepathrombin

Active Ingredient:: Heparin Sodium
Origin:: EU

Hepathrombin (Heparin Sodium)

Q: What is Hepathrombin used for?

Hepathrombin contains heparin sodium, an anticoagulant used to prevent and treat thromboembolic disorders such as deep‑vein thrombosis, pulmonary embolism, and clot formation during dialysis or cardiac surgery. It works by inhibiting key clotting factors to reduce the risk of dangerous blood clots.

Q: How does heparin sodium work in Hepathrombin?

Heparin sodium binds to antithrombin III, dramatically increasing antithrombin's ability to inactivate thrombin (factor IIa) and factor Xa. This blocks the final steps of the coagulation cascade, preventing fibrin formation and thereby reducing clot development.

Q: What is the usual dose of Hepathrombin?

The specific dose of Hepathrombin is determined by the prescribing clinician based on the patient’s condition, weight, renal function, and monitoring results. Dosing regimens vary widely, so the prescriber sets the appropriate amount and frequency.

Q: Is Hepathrombin safe during pregnancy or breastfeeding?

Heparin sodium is classified as a Category B agent in many jurisdictions, indicating limited evidence of risk. It may be used during pregnancy or lactation only when clearly needed and after careful risk‑benefit assessment by the healthcare provider.

Q: How do I order Hepathrombin from GNH India?

To place an order, submit an enquiry on the Hepathrombin product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if required) and necessary import documentation.

Q: How does Hepathrombin compare with other anticoagulants?

Compared with low‑molecular‑weight heparins or direct oral anticoagulants, unfractionated heparin (the form in Hepathrombin) has a shorter half‑life and can be rapidly reversed with protamine sulfate. It offers precise titration via laboratory monitoring but requires more frequent dosing and monitoring for heparin‑induced thrombocytopenia.

Q: What are the storage and handling requirements for Hepathrombin?

Hepathrombin should be stored at ambient temperature, away from direct sunlight and moisture. Keep the product in its original packaging until use, and avoid exposing it to extreme heat or freezing conditions to maintain potency.

Q: How is Hepathrombin administered?

Hepathrombin is administered by subcutaneous injection into the skin. The injection site should be rotated to minimize local irritation, and aseptic technique must be followed to reduce infection risk.

Q: What are the most serious risks associated with Hepathrombin?

The most serious risks include major bleeding events such as intracranial or gastrointestinal hemorrhage, and heparin‑induced thrombocytopenia (HIT), a potentially life‑threatening immune reaction that can paradoxically cause clot formation despite anticoagulation.

Q: Who should not use Hepathrombin?

Patients with known hypersensitivity to heparin or any component of the formulation, those with active major bleeding, or individuals with a history of heparin‑induced thrombocytopenia should not receive Hepathrombin. Clinical judgment is required for patients with severe liver disease or uncontrolled hypertension.

Heparin Sodium, the active ingredient in Hepathrombin, is an anticoagulant presented as a cutaneous formulation for subcutaneous administration. It is employed to prevent and treat thromboembolic conditions by inhibiting clot formation in patients at risk, such as those undergoing surgery or receiving dialysis.

GNH India supplies Hepathrombin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Stada Hemofarm S.R.L.

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Indications & Clinical Uses

Hepathrombin (heparin sodium) acts on the coagulation cascade to reduce clot formation in several clinical settings.

Deep vein thrombosis prophylaxis: helps prevent clot formation after orthopedic or abdominal surgery.
Pulmonary embolism prevention: reduces the risk of embolic events in high‑risk medical patients.
Acute coronary syndrome management: supports anticoagulation during myocardial infarction treatment.
Hemodialysis circuit anticoagulation: maintains patency of extracorporeal blood circuits during renal replacement therapy.
Cardiopulmonary bypass: provides systemic anticoagulation during heart‑lung machine use.

How It Works

Heparin sodium binds to antithrombin III, inducing a conformational change that markedly accelerates antithrombin's inhibition of thrombin (factor IIa) and factor Xa. This enhanced inhibition blocks the conversion of fibrinogen to fibrin and prevents further propagation of the coagulation cascade, thereby reducing the formation of pathological clots.

Side Effects

Heparin sodium may cause a range of adverse reactions, from mild to severe.

Common Side Effects

Local bruising or hematoma at injection site.
Minor bleeding from gums or nose.
Mild thrombocytopenia.
Injection site erythema or itching.
Transient elevation of liver enzymes.

Serious or Rare Side Effects

Heparin‑induced thrombocytopenia (HIT).
Major hemorrhage, including intracranial or gastrointestinal bleeding.
Allergic anaphylactoid reactions.
Spontaneous spinal or epidural hematoma.
Severe thrombocytopenia with platelet count <20,000/µL.

Precautions & Warnings

When using Hepathrombin, clinicians should consider several safety measures.

Renal impairment: adjust monitoring as clearance may be reduced.
Hepatic disease: observe for altered coagulation parameters.
Concomitant antiplatelet or anticoagulant therapy: increase risk of bleeding.
Recent surgery or trauma: assess bleeding risk before administration.
Pregnancy and lactation: use only if clearly needed, after risk‑benefit evaluation.
Store at ambient temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Heparin sodium can interact with several drug classes, influencing its anticoagulant effect.

Major Interactions (Avoid)

Direct thrombin inhibitors (e.g., dabigatran): additive anticoagulation may cause severe bleeding.
Vitamin K antagonists (e.g., warfarin): synergistic effect increases hemorrhagic risk.
Antiplatelet agents (e.g., clopidogrel, aspirin): potentiate bleeding complications.

Moderate Interactions (Monitor Closely)

Non‑steroidal anti‑inflammatory drugs (NSAIDs): may increase minor bleeding.
Glycoprotein IIb/IIIa inhibitors: require careful coagulation monitoring.
Certain antibiotics (e.g., quinolones): can affect platelet function and increase bleeding tendency.

Frequently Asked Questions

Hepathrombin contains heparin sodium, an anticoagulant used to prevent and treat thromboembolic disorders such as deep‑vein thrombosis, pulmonary embolism, and clot formation during dialysis or cardiac surgery. It works by inhibiting key clotting factors to reduce the risk of dangerous blood clots.

Heparin sodium binds to antithrombin III, dramatically increasing antithrombin's ability to inactivate thrombin (factor IIa) and factor Xa. This blocks the final steps of the coagulation cascade, preventing fibrin formation and thereby reducing clot development.

The specific dose of Hepathrombin is determined by the prescribing clinician based on the patient’s condition, weight, renal function, and monitoring results. Dosing regimens vary widely, so the prescriber sets the appropriate amount and frequency.

Heparin sodium is classified as a Category B agent in many jurisdictions, indicating limited evidence of risk. It may be used during pregnancy or lactation only when clearly needed and after careful risk‑benefit assessment by the healthcare provider.

To place an order, submit an enquiry on the Hepathrombin product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if required) and necessary import documentation.

Compared with low‑molecular‑weight heparins or direct oral anticoagulants, unfractionated heparin (the form in Hepathrombin) has a shorter half‑life and can be rapidly reversed with protamine sulfate. It offers precise titration via laboratory monitoring but requires more frequent dosing and monitoring for heparin‑induced thrombocytopenia.

Hepathrombin should be stored at ambient temperature, away from direct sunlight and moisture. Keep the product in its original packaging until use, and avoid exposing it to extreme heat or freezing conditions to maintain potency.

Hepathrombin is administered by subcutaneous injection into the skin. The injection site should be rotated to minimize local irritation, and aseptic technique must be followed to reduce infection risk.

The most serious risks include major bleeding events such as intracranial or gastrointestinal hemorrhage, and heparin‑induced thrombocytopenia (HIT), a potentially life‑threatening immune reaction that can paradoxically cause clot formation despite anticoagulation.

Patients with known hypersensitivity to heparin or any component of the formulation, those with active major bleeding, or individuals with a history of heparin‑induced thrombocytopenia should not receive Hepathrombin. Clinical judgment is required for patients with severe liver disease or uncontrolled hypertension.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated: 29 Jul 2026

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