Hexaflu Day & Night (Diphenhydramine Hydrochloride, Paracetamol | Pseudoephedrine Hydrochloride, Paracetamol)

Hexaflu Day & Night is indicated for temporary relief of several common cold, flu and allergy symptoms.

• Relief of nasal congestion and sinus pressure associated with colds or allergic rhinitis.
• Reduction of headache, muscle aches, and fever through analgesic and antipyretic action.
• Alleviation of sneezing, itchy eyes, and runny nose caused by histamine release.
• Support for daytime symptom control when decongestion is needed without excessive sedation.
• Nighttime use to manage allergy‑related insomnia and discomfort while maintaining pain relief.

• Diphenhydramine hydrochloride blocks H1 histamine receptors, preventing the vascular and sensory effects of histamine that cause itching, sneezing and nasal discharge. Paracetamol exerts analgesic and antipyretic effects by inhibiting central cyclooxygenase enzymes, reducing prostaglandin synthesis in the brain. Pseudoephedrine hydrochloride stimulates α‑adrenergic receptors on nasal mucosal blood vessels, producing vasoconstriction that decreases edema and opens the airway. Overall, the combination targets multiple pathways involved in cold and flu symptomatology.

Like many combination cold medicines, Hexaflu Day & Night may cause a range of adverse reactions, most of which are mild and transient.

Common

• Drowsiness or mild sedation, especially from diphenhydramine.
• Dry mouth, throat or nasal passages.
• Nausea, stomach discomfort or loss of appetite.
• Light‑headedness or mild dizziness.

Serious

• Rapid heart rate, palpitations, or high blood pressure.
• Severe allergic reactions such as rash, itching, swelling, or difficulty breathing.
• Hallucinations or confusion, particularly in older adults.
• Persistent vomiting or signs of liver stress.

Before using Hexaflu Day & Night, consider the following precautions to ensure safe and appropriate use.

• Avoid use if you have known hypersensitivity to any component.
• Use caution in patients with hypertension, heart disease, diabetes, or thyroid disorders.
• Not recommended for children under a specified age without medical advice.
• Limit use if you are taking other products containing paracetamol or decongestants to prevent overdose.
• Pregnant or breastfeeding individuals should consult a healthcare professional before use.
• Alcohol consumption may increase drowsiness and liver strain.

Hexaflu Day & Night can interact with several medicines; reviewing these interactions helps prevent adverse effects.

Avoid

• Other antihistamines, sedatives, or CNS depressants that may enhance drowsiness.
• Additional decongestants or sympathomimetic agents that could raise blood pressure.
• Monoamine‑oxidase inhibitors (MAOIs) or recent MAOI therapy.

Use with caution

• Anticoagulants or antiplatelet drugs, due to potential increased bleeding risk with paracetamol.
• Certain antidepressants (e.g., SSRIs) that may affect serotonin levels.
• Medications metabolized by CYP2D6, as diphenhydramine can inhibit this pathway.