Hexaflu Day & Night (Diphenhydramine Hydrochloride, Paracetamol | Pseudoephedrine Hydrochloride, Paracetamol)

Hexaflu Day & Night is indicated for the temporary relief of several common upper‑respiratory and pain conditions.

• Relief of allergic rhinitis symptoms such as sneezing, itching and watery eyes.
• Reduction of nasal congestion associated with the common cold or sinusitis.
• Alleviation of mild to moderate headache or body aches.
• Lowering of fever caused by viral infections.
• Management of minor pain from sore throat or muscle strain.
• Support for relief of sinus pressure and facial pain.
• Temporary easing of ear congestion during upper‑respiratory infections.

• Diphenhydramine hydrochloride acts as an H1‑receptor antagonist, blocking the action of histamine and reducing allergic symptoms. Paracetamol exerts analgesic and antipyretic effects by inhibiting central cyclooxygenase enzymes, which lowers prostaglandin synthesis in the brain. Pseudoephedrine hydrochloride is a sympathomimetic amine that stimulates α‑adrenergic receptors in the nasal mucosa, causing vasoconstriction and decreasing edema, thereby improving nasal airflow. The combined formulation allows simultaneous management of histamine‑mediated allergy, pain/fever, and nasal congestion.

Like all medicines, Hexaflu Day & Night may cause unwanted effects, most of which are mild, transient, and resolve without medical intervention.

Common

• Drowsiness or mild sedation, particularly after the diphenhydramine component.
• Dry mouth, throat irritation, or occasional blurred vision.
• Nausea, stomach discomfort, or reduced appetite.
• Slight headache or a feeling of restlessness.
• Mild insomnia or difficulty sleeping if taken later in the day.

Serious

• Allergic skin reaction such as rash, itching, swelling, or hives.
• Rapid heartbeat, palpitations, or significant increase in blood pressure.
• Difficulty breathing, tight chest, or severe dizziness that may indicate a serious reaction.
• Unusual mental changes such as confusion, agitation, or hallucinations.

Before using Hexaflu Day & Night, consider the following precautions to ensure safe and appropriate use.

• Do not exceed the recommended daily dose of each active ingredient.
• Avoid use in children under the age specified on the packaging without medical advice.
• Use caution if you have high blood pressure, heart disease, glaucoma, or thyroid disorders.
• Pregnant or breastfeeding individuals should consult a healthcare professional before taking the product.
• Alcohol or other sedating medications may increase drowsiness.
• If symptoms persist longer than a few days, seek medical evaluation.

Hexaflu Day & Night can interact with other medicines; be aware of the following potential interactions.

Avoid

• Monoamine oxidase inhibitors (MAOIs) or other sympathomimetic drugs, which may cause excessive cardiovascular stimulation.
• Other antihistamines or sedatives, which can increase drowsiness.
• Additional paracetamol‑containing products, to avoid exceeding the safe daily limit.
• Certain decongestant nasal sprays, which may cause additive vasoconstriction.

Use with caution

• Blood pressure medications, as pseudoephedrine may reduce their effectiveness.
• Antidepressants such as SSRIs or tricyclics, which may increase the risk of serotonin syndrome.
• Alcohol, which can enhance sedation from diphenhydramine.
• Anticoagulants or antiplatelet agents, because paracetamol may increase bleeding risk.