Hexomedine Lösung (Hexamidine Diisetionate)

Hexomedine Lösung is used as a skin antiseptic in various settings where microbial control is required.

• Pre‑operative skin preparation before minor surgical or invasive procedures.
• Cleansing of intact skin prior to catheter or needle insertion.
• Treatment of minor cuts, abrasions, and superficial burns to reduce infection risk.
• Disinfection of skin after exposure to contaminated surfaces or substances.
• Routine antiseptic cleansing in healthcare facilities and home care environments.

• Hexamidine diisetionate belongs to the bisbiguanide class of antiseptics. It exerts its antimicrobial effect by binding to negatively charged components of microbial cell membranes, leading to increased permeability and loss of essential intracellular ions. This disruption interferes with metabolic processes and ultimately results in cell death for a broad range of bacteria and some fungi, while remaining poorly absorbed through intact skin.

Adverse reactions to Hexomedine Lösung are generally mild, but occasional more serious events have been reported.

Common

• Local skin irritation or redness.
• Mild itching or burning sensation at the application site.
• Dryness or peeling of the treated skin.
• Transient tingling or mild swelling.

Serious

• Allergic contact dermatitis with swelling, vesicles, or extensive rash.
• Severe hypersensitivity reactions such as urticaria or angioedema.
• Rare anaphylactic shock requiring emergency care.
• Very rare systemic toxicity if applied to large broken skin areas.

When using Hexomedine Lösung, certain precautions help minimize risks and ensure safe application.

• Do not apply to mucous membranes, eyes, or internal body cavities.
• Avoid use on large areas of damaged or broken skin.
• Discontinue use if signs of allergic reaction appear.
• Keep the solution out of reach of children and pets.
• Store in a cool, dry place away from direct sunlight.
• Use only as directed; do not exceed recommended frequency.

Hexomedine Lösung may interact with other topical agents or systemic medications, requiring attention to avoid reduced efficacy or increased irritation.

Avoid

• Concurrent application with other antiseptic or disinfectant solutions on the same skin area.
• Use together with topical corticosteroids or immunosuppressants on compromised skin.
• Mixing with alcohol‑based hand rubs that may increase skin irritation.

Use with caution

• Applying over skin pre‑treated with chemical peels or retinoids.
• Use in patients receiving systemic antibiotics for the same infection site.
• Co‑application with wound dressings containing adhesive that may trap the solution.