Hexarhinal Plus Kids (Xylometazoline Hydrochloride, Dexpanthenol)

Hexarhinal Plus Kids is indicated for the short‑term, topical relief of nasal blockage in children caused by various upper‑respiratory conditions.

• Nasal congestion associated with the common cold, helping to ease breathing.
• Nasal blockage related to acute sinusitis, reducing mucosal swelling.
• Allergic rhinitis‑induced stuffiness, providing decongestion during allergen exposure.
• Upper respiratory tract infections with mild edema of the nasal passages.
• Post‑viral nasal obstruction in pediatric patients, supporting quicker recovery.

• Xylometazoline hydrochloride acts as an α‑adrenergic agonist, binding to α1‑adrenergic receptors on the vascular smooth muscle of the nasal mucosa. This stimulates vasoconstriction, decreasing blood flow and reducing edema, which opens the nasal airway. Dexpanthenol, a precursor of pantothenic acid, is converted to co‑enzyme A in epithelial cells, promoting cellular repair and providing a moisturizing, soothing effect on the irritated nasal lining.

Like most topical nasal decongestants, Hexarhinal Plus Kids may cause local or systemic reactions, most of which are mild and reversible.

Common

• Transient nasal irritation or burning sensation.
• Mild dryness of the nasal mucosa.
• Sneezing or mild headache.
• Temporary taste disturbance.
• Throat irritation or mild cough.

Serious

• Nasal bleeding (epistaxis) especially with prolonged use.
• Severe allergic reaction such as rash, swelling, or difficulty breathing.
• Persistent nasal congestion due to rebound effect after more than three days of use.
• Elevated blood pressure in children with pre‑existing cardiovascular conditions.

Before using Hexarhinal Plus Kids, caregivers should consider several safety precautions to minimize risks and ensure appropriate use in children.

• Do not use in children younger than two years of age unless directed by a physician.
• Limit treatment to a maximum of three consecutive days to avoid rebound congestion.
• Avoid use if the child has a known hypersensitivity to xylometazoline, dexpanthenol, or any formulation components.
• Consult a healthcare professional before use during pregnancy or breastfeeding, as safety data are limited.
• Discontinue the product and seek medical advice if nasal bleeding or severe irritation occurs.
• Keep the spray out of reach of children to prevent accidental overdose.

Hexarhinal Plus Kids may interact with other medications or substances that affect nasal blood flow or systemic adrenergic activity.

Avoid

• Concurrent use of other topical nasal decongestants (e.g., oxymetazoline, phenylephrine) to prevent excessive vasoconstriction.
• Systemic sympathomimetic drugs such as pseudoephedrine when combined with the nasal spray.
• Nasal sprays containing corticosteroids may reduce efficacy if used simultaneously.

Use with caution

• Antihypertensive agents, as nasal vasoconstriction could modestly raise blood pressure.
• Monoamine oxidase inhibitors (MAOIs) or tricyclic antidepressants, due to potential additive cardiovascular effects.
• Cardiac glycosides or beta‑blockers in children, requiring monitoring of heart rate and blood pressure.
• Herbal supplements containing ephedra or similar stimulants.