Hextril (Hexetidine)

Hextril is indicated for several common oral conditions where microbial control is needed. It is used to manage and prevent infections of the mouth and gums.

• Treatment of oral mucosal infections such as aphthous ulcers
• Management of gingivitis and related gum inflammation
• Relief of symptoms associated with stomatitis
• Prevention of oral thrush in at‑risk individuals
• Adjunctive care after dental procedures to reduce microbial load

• Hexetidine exerts its antiseptic effect by integrating into microbial cell membranes, disrupting lipid bilayer integrity. This leads to increased permeability, loss of essential intracellular components, and ultimately cell death. The action is non‑specific, affecting a wide range of bacteria, fungi, and enveloped viruses present in the oral cavity, thereby reducing microbial colonisation and infection risk.

Adverse reactions to Hextril are generally mild, but serious events can occur in susceptible individuals.

Common

• Transient burning or stinging sensation in the mouth
• Altered taste perception or metallic taste
• Mild irritation of the oral mucosa
• Dry mouth or slight dryness of the throat
• Nausea or mild gastrointestinal discomfort

Serious

• Allergic reactions such as rash, itching, or urticaria
• Angioedema involving lips, tongue, or face
• Severe mucosal ulceration or erosions
• Persistent swelling of the oral tissues
• Anaphylactic shock (rare)

Before using Hextril, consider the following safety points to minimise risk.

• Do not use if you have a known hypersensitivity to hexetidine or any formulation ingredients.
• Avoid prolonged use without professional guidance, especially in children.
• Discontinue use and seek medical advice if signs of an allergic reaction appear.
• Use caution in patients with existing oral lesions or severe mucosal damage.
• Pregnant or breastfeeding individuals should consult a healthcare provider before use.
• Keep the product out of reach of children to prevent accidental ingestion.

Hextril may interact with other oral products or systemic medications. Review the following guidance.

Avoid

• Concurrent use of other antiseptic mouthwashes containing chlorhexidine, as combined effects may increase irritation.
• Application of topical corticosteroids or immunosuppressants in the same area without professional advice.

Use with caution

• Alcohol‑based oral rinses, which may enhance mucosal dryness.
• Antifungal agents, as overlapping antimicrobial activity could affect oral flora balance.
• Systemic antibiotics, where altered oral microbiota may influence gastrointestinal side effects.
• Herbal or natural oral care products that could cause additive taste disturbances.