Hibiscrub (Chlorhexidine Gluconate)

Hibiscrub is used as a topical antiseptic for a variety of skin‑related procedures and situations where microbial control is required.

• Skin antisepsis before minor procedures or injections.
• Pre‑operative skin preparation for surgical sites.
• Cleaning of superficial wounds, cuts, and abrasions.
• Disinfection of intact skin prior to catheter or IV insertion.
• Reducing bacterial colonisation on hands of healthcare workers in clinical settings.
• Antiseptic hand washing in community or institutional environments.

• Chlorhexidine gluconate exerts its antiseptic effect by binding to negatively charged bacterial cell walls and disrupting membrane integrity. The cationic molecules insert into the phospholipid bilayer, increasing permeability and causing leakage of intracellular contents. This loss of essential ions and metabolites leads to rapid bacterial cell death. The action is concentration‑dependent and effective against Gram‑positive and Gram‑negative bacteria, as well as some fungi and viruses.

Adverse reactions to Hibiscrub are generally limited to the site of application, but occasional systemic effects have been reported.

Common

• Mild skin irritation or redness that usually resolves within a few hours.
• Transient itching, burning, or stinging sensation at the treated area.
• Dryness, flaking, or mild peeling of the skin after repeated use.

Serious

• Allergic contact dermatitis characterized by redness, swelling, vesicles, or intense itching.
• Severe skin ulceration or necrosis, particularly with prolonged exposure or occlusion.
• Systemic hypersensitivity such as anaphylaxis, presenting with hives, airway swelling, or low blood pressure.

When using Hibiscrub, certain precautions help minimise adverse reactions and ensure effective antisepsis.

• Do not apply to mucous membranes, eyes, or internal body cavities.
• Avoid use on large areas of broken skin or extensive burns.
• Keep the product away from open wounds that are deep or heavily contaminated unless directed by a healthcare professional.
• Discontinue use and seek medical advice if signs of an allergic reaction develop.
• Store at room temperature, protected from light and moisture, and keep out of reach of children.
• Do not use on infants younger than two months without professional guidance.

Chlorhexidine gluconate can interact with certain substances, affecting its antiseptic performance or increasing irritation risk.

Avoid

• Products containing anionic surfactants (e.g., soaps, shampoos) that can inactivate chlorhexidine.
• Alcohol‑based hand rubs applied immediately after Hibiscrub, which may reduce antimicrobial activity.
• Saline or aqueous solutions that dilute the preparation before application, reducing its concentration.

Use with caution

• Topical antibiotics or corticosteroids applied to the same area, which may alter skin absorption.
• Wound dressings containing iodine, as combined use can increase local irritation.
• Concurrent use of other topical antiseptics, requiring monitoring for cumulative skin reactions.