Hibitane (Chlorhexidine Gluconate)

Hibitane is indicated for external vaginal antisepsis and for helping prevent common vaginal infections.

• Routine vaginal cleansing before gynecological examinations or procedures.
• Adjunctive care after childbirth to support vaginal hygiene.
• Use as a prophylactic measure before sexual activity to reduce microbial load.
• Management of mild irritation or odor associated with bacterial overgrowth.
• Supportive treatment in conjunction with other prescribed therapies for bacterial vaginosis prevention.
• Temporary relief of itching or discomfort following exposure to irritants such as soaps or douches.

• Chlorhexidine gluconate exerts its antiseptic effect by binding to negatively charged bacterial cell walls, disrupting membrane integrity and precipitating intracellular contents. The compound penetrates the lipid bilayer, causing leakage of essential ions and loss of metabolic function, which leads to rapid bacterial cell death. Its broad‑spectrum activity covers Gram‑positive and Gram‑negative organisms commonly found in the vaginal flora and yeasts.

Local application of Hibitane may be associated with mild to moderate adverse reactions, most of which are reversible after discontinuation.

Common

• Transient burning or stinging sensation at the site of application.
• Mild vaginal irritation or redness.
• Slight itching or discomfort.
• Temporary increase in vaginal discharge.
• Mild dryness of the vaginal walls.
• Temporary discoloration of the surrounding skin.
• Mild swelling of the labial tissue.

Serious

• Severe allergic reaction presenting as swelling, hives, or difficulty breathing.
• Persistent ulceration or erosions of the vaginal mucosa.
• Contact dermatitis extending beyond the application area.
• Rare cases of systemic toxicity with symptoms such as dizziness or nausea.

Before using Hibitane, certain precautions should be observed to minimize the risk of irritation or adverse reactions.

• Do not apply to broken, inflamed, or ulcerated mucosa.
• Avoid internal vaginal use beyond the recommended surface area.
• Perform a small patch test on adjacent skin if you have a history of sensitivity to chlorhexidine.
• Discontinue use and consult a healthcare professional if severe irritation or allergic symptoms develop.
• Keep the product out of reach of children and store it at room temperature away from direct sunlight.
• Do not use concurrently with other vaginal antiseptics unless directed by a clinician.
• Pregnant or breastfeeding individuals should seek medical advice before use.

When using Hibitane, be aware of potential interactions with other products applied to the vaginal area or systemic agents that may affect mucosal integrity.

Avoid

• Simultaneous use of other chlorhexidine‑containing vaginal products, which can increase irritation.
• Application of spermicidal gels or lubricants containing non‑ionic surfactants immediately after Hibitane.
• Use together with topical antibiotics or antifungals without professional guidance.

Use with caution

• Concurrent use of hormonal contraceptives delivered vaginally (e.g., rings) – monitor for local irritation.
• Systemic antihistamines that may mask early signs of an allergic reaction.
• Use in patients receiving chemotherapy or radiation therapy to the pelvic region – mucosal sensitivity may be heightened.