Hidrocloruro De Fenilefrina Altan 10 Mg/Ml (Phenylephrine Hydrochloride)

Hidrocloruro De Fenilefrina Altan is employed in clinical settings where rapid vasoconstriction is needed. It is commonly used for:

• Treatment of acute hypotension, especially during anesthesia or shock.
• Relief of nasal congestion caused by allergic or viral rhinitis.
• Management of upper airway edema, such as after intubation or surgery.
• Adjunct therapy for certain types of bronchial obstruction.
• Supportive care in patients with severe allergic reactions where airway swelling is present.

• Phenylephrine hydrochloride acts as a selective alpha‑1 adrenergic receptor agonist. By binding to these receptors on vascular smooth muscle, it triggers phosphatidylinositol‑calcium signaling that leads to vasoconstriction. The resulting increase in peripheral vascular resistance raises blood pressure and reduces mucosal edema, thereby improving airway patency and relieving congestion.

Adverse reactions to phenylephrine may vary in frequency and severity.

Common

• Headache
• Palpitations or tachycardia
• Hypertension or transient blood pressure elevation
• Nausea or vomiting
• Local irritation at the injection site

Serious

• Severe hypertension with risk of end‑organ damage
• Cardiac arrhythmias, including atrial fibrillation
• Reflex bradycardia
• Ischemic chest pain or myocardial infarction
• Cerebral hemorrhage in susceptible individuals

Use of phenylephrine requires careful assessment of patient risk factors. Consider the following precautions:

• Assess baseline blood pressure; avoid use in uncontrolled hypertension.
• Monitor cardiac rhythm in patients with known arrhythmias.
• Use cautiously in patients with coronary artery disease or recent myocardial infarction.
• Evaluate for hyperthyroidism, as increased catecholamine sensitivity may amplify effects.
• Adjust dose or avoid in patients receiving monoamine oxidase inhibitors (MAOIs).
• Pregnant or nursing patients should be managed only if benefits outweigh potential risks.

Phenylephrine can interact with several medication classes. Relevant interactions include:

Avoid

• Concurrent use with other potent vasoconstrictors (e.g., norepinephrine, epinephrine) due to additive hypertension risk.
• MAO inhibitors, which may potentiate hypertensive responses.
• Tricyclic antidepressants that increase norepinephrine levels.

Use with caution

• Beta‑blockers, which may mask tachycardia while allowing blood pressure rise.
• Diuretics or antihypertensives, as phenylephrine may counteract their effects.
• Lithium, because altered renal perfusion can affect lithium clearance.