Hirudoid (Chondroitin Polysulfate)

Hirudoid is commonly applied to the skin for conditions that benefit from its anti‑inflammatory and anti‑edematous properties.

• Minor bruises (contusions) and superficial hematomas.
• Small sprains or strains involving skin and subcutaneous tissue.
• Post‑traumatic swelling or edema of the skin.
• Superficial skin irritations such as mild dermatitis where inflammation is present.
• After minor surgical procedures to reduce localized swelling.

• Chondroitin polysulfate is a sulfated glycosaminoglycan that interferes with the activity of inflammatory mediators, including histamine and prostaglandins. It reduces vascular permeability and limits the migration of leukocytes into the extracellular space, thereby decreasing local edema and inflammation when applied to the skin. The compound also supports the stability of the extracellular matrix, contributing to tissue repair processes.

Adverse skin reactions may occur with topical use of Hirudoid.

Common

• Mild erythema or redness at the application site.
• Itching or mild pruritus.
• Transient burning or stinging sensation.
• Dryness or flaking of the skin.

Serious

• Allergic contact dermatitis with vesiculation.
• Urticaria or widespread hives.
• Severe skin necrosis or ulceration.
• Systemic hypersensitivity reactions such as angioedema.

Before using Hirudoid, consider the following safety points.

• Avoid application on open wounds, cuts, or infected skin.
• Do not use if you have a known hypersensitivity to chondroitin polysulfate or any excipients.
• Test a small skin area first to assess for local irritation.
• Keep the product away from eyes, mucous membranes, and the oral cavity.
• Discontinue use and seek medical advice if a serious skin reaction develops.
• Consult a healthcare professional before using on children or during pregnancy.

Topical Hirudoid may interact with other skin products.

Avoid

• Concurrent use with other topical anti‑inflammatory agents without professional guidance.
• Application over products containing strong irritants or corrosive chemicals.

Use with caution

• Other medicated creams or ointments that may increase skin absorption.
• Occlusive dressings that could enhance local concentration.
• Products containing alcohol or high concentrations of fragrance.
• Systemic medications that affect coagulation, if extensive skin areas are treated.