Hirudoid Forte (Chondroitin Polysulfate)

Hirudoid Forte is indicated for several superficial vascular and traumatic skin conditions where improved microcirculation and reduced inflammation are desired. The topical gel is used by healthcare professionals to support the natural resolution of these conditions.

• Superficial thrombophlebitis, providing local antithrombotic effect.
• Bruises and hematomas, facilitating resorption of blood collections.
• Localized edema, helping to reduce swelling.
• Symptoms of varicose veins, such as discomfort and skin changes.
• Minor inflammatory skin lesions where improved microcirculation is beneficial.

• Chondroitin polysulfate is a sulfated glycosaminoglycan that mimics the activity of endogenous heparin. When applied to the skin, it penetrates the epidermis and binds to coagulation factors, particularly thrombin and factor Xa, inhibiting their activity. The compound also interferes with the complement cascade and reduces the release of inflammatory mediators such as prostaglandins and cytokines. These actions improve capillary permeability, enhance venous return, and promote the breakdown of extravasated blood.

Topical application of Hirudoid Forte may be associated with local skin reactions and, rarely, systemic effects.

Common

• Mild skin irritation or erythema at the application site.
• Pruritus (itching) localized to the treated area.
• Transient burning or stinging sensation upon first use.
• Dryness or peeling of the skin where the product is applied.

Serious

• Allergic contact dermatitis with vesiculation or widespread rash.
• Severe skin necrosis or ulceration (very rare).
• Systemic hypersensitivity reactions such as angio‑edema.
• Unexplained bleeding or bruising extension beyond the treated area.

Before using Hirudoid Forte, consider the following precautions to minimize risks and ensure appropriate use.

• Do not apply to broken skin, open wounds, or infected lesions.
• Avoid use on mucous membranes, eyes, or genital areas.
• Discontinue the product if signs of allergic reaction develop.
• Use with caution in patients with known heparin sensitivity or coagulation disorders.
• Pregnant or breastfeeding individuals should consult a healthcare professional prior to use.
• Keep the product out of reach of children and store at room temperature away from direct sunlight.

Hirudoid Forte may interact with other topical agents or systemic medications that affect coagulation or skin integrity.

Avoid

• Concurrent application of other heparinoid or anticoagulant creams.
• Use together with potent topical corticosteroids on the same area.
• Application over areas treated with chemical peels or laser therapy.

Use with caution

• Systemic anticoagulants (e.g., warfarin, direct oral anticoagulants) if large skin areas are treated.
• Non‑steroidal anti‑inflammatory drugs (NSAIDs) applied topically nearby.
• Products containing retinoids or other irritant cosmetics.