Hirudoid Forte (Chondroitin Polysulfate)

Hirudoid Forte is indicated for several superficial vascular and inflammatory skin conditions where localized treatment is preferred.

• Management of bruising (ecchymosis) resulting from trauma or surgery.
• Treatment of hematoma to reduce swelling and promote resolution.
• Supportive care for superficial thrombophlebitis to improve venous flow.
• Relief of mild inflammatory skin conditions such as localized edema.
• Adjunct therapy for post‑procedural skin discoloration.

• Chondroitin polysulfate acts as a heparinoid by binding to antithrombin III and inhibiting key coagulation factors, which reduces fibrin formation in the microvasculature. It also stabilizes endothelial cells, decreasing vascular permeability and limiting the extravasation of blood components. These actions collectively provide localized anticoagulant and anti‑inflammatory effects on the skin without significant systemic absorption.

Adverse reactions to Hirudoid Forte are generally mild and limited to the application site.

Common

• Mild skin irritation or erythema at the site of application.
• Pruritus or itching.
• Transient burning sensation.
• Dryness or peeling of the treated skin.

Serious

• Allergic contact dermatitis with vesiculation.
• Severe localized edema or urticaria.
• Development of necrotic skin lesions (rare).
• Systemic hypersensitivity reactions such as angioedema.

When using Hirudoid Forte, consider the following safety measures to minimize risks.

• Avoid application on broken, infected, or ulcerated skin.
• Do not use on large surface areas or under occlusive dressings unless directed by a healthcare professional.
• Discontinue use if signs of allergic reaction appear and seek medical advice.
• Pregnant or breastfeeding individuals should consult a physician before use.
• Keep out of reach of children; accidental ingestion requires immediate medical attention.
• Store at room temperature, protected from excessive heat and moisture.

Topical chondroitin polysulfate may interact with other agents applied to the same skin area.

Avoid

• Concurrent use with other topical anticoagulants (e.g., heparin creams) without medical supervision.
• Application over areas treated with potent corticosteroids or non‑steroidal anti‑inflammatory gels.

Use with caution

• Combining with systemic anticoagulant therapy (e.g., warfarin) if extensive skin coverage is planned.
• Use alongside other heparinoid‑containing products in adjacent regions.
• Application in patients using topical antibiotics, as irritation may increase absorption.
• Use in individuals with known hypersensitivity to chondroitin derivatives.