Hirudoid Gel (Chondroitin Polysulfate)

Hirudoid Gel is indicated for several superficial vascular and inflammatory skin conditions where local treatment is appropriate. It is commonly employed in the following situations:

• Bruising (contusions) resulting from minor trauma.
• Hematoma formation in soft tissue.
• Superficial thrombophlebitis affecting small veins.
• Minor contusions and ecchymoses on the limbs.
• Post‑procedural skin discoloration where inflammation is present.
• Supportive care for mild skin swelling associated with injury.

• Chondroitin polysulfate in Hirudoid Gel acts as a glycosaminoglycan that interferes with the coagulation cascade when applied to the skin. It inhibits thrombin activity, reduces fibrin formation, and limits platelet aggregation at the site of application. By modulating these pathways, the gel diminishes local inflammation and prevents micro‑thrombus development, leading to reduced swelling and discoloration in superficial tissues.

Adverse reactions to Hirudoid Gel are generally mild and limited to the area of application. They are categorized as follows:

Common

• Mild skin irritation or redness.
• Itching at the site of application.
• Slight burning sensation.
• Dryness or peeling of the treated skin.

Serious

• Allergic contact dermatitis with swelling and rash.
• Severe skin ulceration or necrosis (rare).
• Systemic hypersensitivity reactions such as hives.
• Persistent erythema extending beyond the treated area.

Before using Hirudoid Gel, consider the following safety points:

• Avoid applying to broken, infected, or ulcerated skin.
• Do not use on large surface areas or for prolonged periods without medical advice.
• Discontinue use if signs of allergic reaction appear.
• Keep the gel out of reach of children; accidental ingestion should be avoided.
• Consult a healthcare professional before use during pregnancy or lactation.
• Store at room temperature, away from direct sunlight and moisture.
• Do not apply under occlusive dressings unless directed by a clinician.

Topical chondroitin polysulfate may interact with other skin products or systemic agents. Consider these guidelines:

Avoid

• Concurrent use with other topical anticoagulants or antiplatelet agents.
• Application over areas treated with strong irritants or chemical peels.

Use with caution

• Combining with other NSAID gels or creams may increase irritation risk.
• Use alongside systemic anticoagulants (e.g., warfarin) only under medical supervision.
• Applying over extensive burns or large wounds may enhance systemic absorption.
• Use with other glycosaminoglycan‑containing products may potentiate local effects.