Holland & Barrett Over Indulgence (Dry Extract From Milk Thistle Fruit, (Equivalent To 3.725 G – 10.818 G Of Milk Thistle Fruits) Corre)

Holland & Barrett Over Indulgence is commonly used as a complementary approach to support liver function and overall detoxification.

• Supports normal liver metabolism during periods of increased dietary or environmental stress.
• Provides antioxidant protection to hepatocytes, helping to neutralise free radicals.
• May assist in maintaining healthy cholesterol levels as part of a balanced diet.
• Used by individuals seeking natural support during alcohol consumption or exposure to mild toxins.
• Complementary to lifestyle measures such as reduced alcohol intake and regular exercise.

• The milk‑thistle fruit extract contains silymarin, a mixture of flavonolignans that exhibit antioxidant activity. Silymarin scavenges reactive oxygen species and stabilises cell membranes, thereby protecting hepatocytes from oxidative damage. It also modulates intracellular signalling pathways, enhancing protein synthesis and promoting regeneration of liver cells. Additionally, silymarin can inhibit the binding of toxins to hepatic receptors, supporting the liver’s detoxification capacity.

Adverse reactions to milk‑thistle fruit extract are generally mild, but occasional reports of more serious events exist.

Common

• Mild gastrointestinal discomfort such as bloating, nausea or diarrhoea.
• Headache or transient dizziness.
• Allergic skin reactions including itching or rash.

Serious

• Severe allergic reactions (anaphylaxis) with difficulty breathing or swelling of the face and throat.
• Liver enzyme elevations in susceptible individuals.
• Persistent vomiting or severe abdominal pain.

When considering Holland & Barrett Over Indulgence, certain precautions should be observed to minimise risk.

• Not recommended for pregnant or breastfeeding women due to limited safety data.
• Individuals with known allergy to milk‑thistle or related plants should avoid the product.
• Persons taking anticoagulant or antiplatelet medication should consult a healthcare professional before use.
• Those with chronic liver disease should seek medical advice prior to supplementation.
• Avoid exceeding the recommended daily intake indicated on the label.
• Keep the product out of reach of children.

Milk‑thistle extract can affect the activity of several medicines, so awareness of potential interactions is important.

Avoid

• Anticoagulants such as warfarin, as silymarin may enhance bleeding risk.
• Hormonal therapies (e.g., oral contraceptives, hormone replacement) because of possible alterations in hormone metabolism.

Use with caution

• Antidiabetic drugs, as silymarin may influence blood‑glucose levels.
• CYP450‑metabolised medications (e.g., statins, certain antidepressants) due to enzyme inhibition.
• Immunosuppressants, because of theoretical effects on drug clearance.