Hooikoortstabletten Cetirizine Dihcl Kruidvat (Cetirizine Dihydrochloride)

Hooikoortstabletten Cetirizine Dihcl Kruidvat is indicated for the temporary relief of symptoms associated with allergic conditions.

• Seasonal allergic rhinitis (hay fever)
• Perennial allergic rhinitis
• Acute urticaria (hives)
• Itchy skin caused by allergic reactions
• Relief of sneezing, runny nose, and watery eyes due to pollen or dust exposure

• Cetirizine dihydrochloride is a selective peripheral H1‑receptor antagonist. By binding to the H1 receptors on mast cells, basophils and other cells, it prevents histamine released during an allergic response from attaching to its receptor sites. This blockade reduces the downstream signaling that leads to vasodilation, increased vascular permeability, and sensory nerve activation, thereby diminishing the typical signs of an allergic reaction without crossing the blood‑brain barrier in significant amounts.

Like all antihistamines, cetirizine may cause unwanted effects, most of which are mild and reversible.

Common

• Drowsiness or mild sedation
• Dry mouth
• Headache
• Nausea or abdominal discomfort

Serious

• Severe skin rash or Stevens‑Johnson syndrome
• Angioedema (swelling of face, lips, tongue)
• Anaphylactic reaction requiring immediate medical attention

Before using Hooikoortstabletten Cetirizine Dihcl Kruidvat, consider the following safety points.

• Do not use if you have a known hypersensitivity to cetirizine or other antihistamines.
• Use with caution in patients with severe renal impairment; dose adjustment may be required.
• Avoid during pregnancy or breastfeeding unless advised by a healthcare professional.
• May cause sedation; avoid operating machinery or driving if affected.
• Concomitant alcohol consumption can increase drowsiness.
• This product is not a substitute for emergency treatment of anaphylaxis.

Cetirizine can interact with other medicines, altering its effectiveness or increasing side‑effect risk.

Avoid

• Alcohol, which can enhance sedation.
• Central nervous system depressants such as benzodiazepines or opioids.
• Other antihistamines, which may cause additive sedation.

Use with caution

• Theophylline, which may reduce cetirizine's antihistaminic effect.
• Strong CYP3A4 inhibitors (e.g., ketoconazole, erythromycin) that could increase cetirizine plasma levels.
• Antacids containing aluminum or magnesium, which may affect absorption.