Humagrip (Chlorphenamine Maleate, Paracetamol | Pseudoephedrine Hydrochloride, Paracetamol)

Humagrip is indicated for the temporary relief of several common cold and flu symptoms, providing a combined antihistamine, decongestant and analgesic effect.

• Nasal congestion and sinus pressure relief through vasoconstriction of nasal blood vessels.
• Fever, headache and body‑ache reduction by inhibiting prostaglandin synthesis.
• Sore throat, runny nose, sneezing and itchy eyes relief via antihistamine action.
• Improved breathing comfort during mild to moderate sinusitis or upper‑respiratory irritation.
• General comfort for flu‑like malaise and chill‑related discomfort.

• Chlorphenamine maleate acts as an H1‑receptor antagonist, blocking histamine‑mediated allergic responses. Pseudoephedrine hydrochloride is a sympathomimetic amine that stimulates α‑adrenergic receptors in the nasal mucosa, causing vasoconstriction and reduced swelling. Paracetamol (acetaminophen) inhibits cyclo‑oxygenase enzymes in the central nervous system, lowering prostaglandin production to reduce pain and fever. The combined actions address multiple pathways involved in cold and flu symptomatology.

Like all combination cold medicines, Humagrip may cause unwanted effects, most of which are mild, transient, and dose‑related. Patients should be aware of both frequently observed reactions and the less common but potentially serious events.

Common

• Drowsiness or mild sedation, especially when standing up quickly.
• Dry mouth, throat irritation or a feeling of cotton‑mouth.
• Nausea, mild stomach upset or loss of appetite.
• Restlessness, nervousness or difficulty falling asleep.

Serious

• Rapid heart rate (tachycardia) or palpitations that may be felt in the chest.
• Elevated blood pressure or sudden spikes, particularly in sensitive individuals.
• Severe allergic reaction, including rash, itching, swelling of the face or throat, and breathing difficulty.
• Hallucinations, severe confusion or agitation, which require immediate medical attention.

Humagrip should be used with caution in certain populations and health conditions to minimise risk.

• Not recommended for children under a specified age without medical advice, due to pseudoephedrine content.
• Avoid use if you have uncontrolled hypertension, severe coronary artery disease, or recent heart surgery.
• Use cautiously in patients with glaucoma, diabetes, thyroid disorders, or enlarged prostate.
• Pregnant or breastfeeding women should consult a healthcare professional before taking Humagrip.
• Individuals taking monoamine‑oxidase inhibitors (MAOIs) or other serotonergic drugs should seek medical guidance.
• Alcohol consumption may increase drowsiness and liver strain when combined with paracetamol.

Humagrip can interact with other medicines; some combinations should be avoided while others require careful monitoring.

Avoid

• Other products containing paracetamol or acetaminophen, to prevent liver toxicity.
• Additional decongestants or sympathomimetic agents, which may raise blood pressure excessively.
• MAO inhibitors or other serotonergic drugs, due to risk of hypertensive crisis or serotonin syndrome.

Use with caution

• Antihypertensive medications, as pseudoephedrine may reduce their effectiveness.
• Anticoagulants or antiplatelet agents, because paracetamol can affect bleeding risk.
• Sedating antihistamines or CNS depressants, which may enhance drowsiness.