Product image of Macroagregados De Albúmina Humana Curium (Human Albumin As Macroaggregates) supplied by GNH India

Macroagregados De Albúmina Humana Curium

Active Ingredient:
Human Albumin As Macroaggregates
Origin:
EU

Macroagregados De Albúmina Humana Curium (Human Albumin As Macroaggregates)

Human albumin macroaggregates, the active ingredient in Macroagregados De Albúmina Humana Curium, is a plasma protein presented as a sterile solution for intravenous use. It is employed to increase plasma oncotic pressure and expand intravascular volume in patients with hypovolemia, shock, severe burns, or hypoalbuminemia.
GNH India supplies Macroagregados De Albúmina Humana Curium as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Cis Bio International

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Indications & Clinical Uses

Human albumin macroaggregates acts as a plasma volume expander in conditions of reduced circulating blood volume.

  • Hypovolemia: restores intravascular volume and improves tissue perfusion.
  • Shock: supports circulatory stability during acute circulatory failure.
  • Severe burns: compensates for protein loss and fluid shifts.
  • Hypoalbuminemia: raises serum albumin levels and oncotic pressure.

How It Works

  • Human albumin macroaggregates increase plasma oncotic pressure by adding colloidal protein to the bloodstream, which draws water from the interstitial space into the vascular compartment, thereby expanding intravascular volume and improving hemodynamic stability.

Side Effects

Human albumin macroaggregates may be associated with a range of adverse reactions.

Common Side Effects

  • Fever or chills during infusion.
  • Transient hypotension or hypertension.
  • Mild allergic skin reactions such as rash or urticaria.
  • Headache or dizziness.
  • Nausea or vomiting.
  • Local infusion site irritation.

Serious or Rare Side Effects

  • Anaphylactic or severe allergic reaction.
  • Pulmonary edema due to rapid volume overload.
  • Coagulopathy or bleeding abnormalities.
  • Acute renal impairment.
  • Thromboembolic events.
  • Severe electrolyte disturbances.

Precautions & Warnings

Human albumin macroaggregates should be used with careful clinical monitoring.

  • Volume status assessment: evaluate fluid balance before and during therapy.
  • Albumin level monitoring: check serum albumin to guide dosing.
  • Cardiac caution: avoid rapid infusion in patients with heart failure.
  • Hypersensitivity screening: contraindicated in known allergy to albumin products.
  • Co‑administration with diuretics: monitor electrolytes closely.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Human albumin macroaggregates can interact with other medications affecting fluid balance or coagulation.

Major Interactions (Avoid)

  • Concurrent use with other colloid volume expanders may cause fluid overload.
  • Simultaneous administration with high‑dose diuretics can precipitate severe electrolyte shifts.
  • Combination with ACE inhibitors in unstable patients may exacerbate hypotension.

Moderate Interactions (Monitor Closely)

  • Anticoagulants: monitor for altered bleeding risk.
  • Nephrotoxic agents: assess renal function regularly.
  • Corticosteroids: watch for enhanced fluid retention.

Frequently Asked Questions

Macroagregados De Albúmina Humana Curium contains human albumin macroaggregates, a plasma protein used as a volume expander to treat hypovolemia, shock, severe burns, and hypoalbuminemia by increasing intravascular oncotic pressure.

The macroaggregates add colloidal protein to the bloodstream, raising plasma oncotic pressure. This draws fluid from the interstitial space into the vascular compartment, expanding circulating volume and supporting blood pressure and tissue perfusion.

The appropriate dose is determined by the prescribing clinician based on the patient’s clinical condition, weight, and laboratory values. Dosing is individualized and administered intravenously under medical supervision.

Safety data for human albumin macroaggregates in pregnancy and lactation are limited. The product should only be used if the potential benefit justifies any potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Human albumin macroaggregates are a natural plasma protein, offering oncotic support without the synthetic components found in some colloids. Compared with crystalloids, they provide more sustained volume expansion, while compared with other albumin solutions they are presented as macroaggregates, which may affect distribution and clearance characteristics.

Store the product at 2‑8 °C, protected from light. Keep it in the original container, do not freeze, and avoid shaking the vial. Inspect for particulate matter before use and discard if the solution appears discolored or compromised.

The solution is given intravenously, typically via a controlled infusion pump or gravity drip. Administration rate should be adjusted according to the patient’s hemodynamic response and monitored continuously by qualified medical staff.

Serious risks include anaphylactic reactions, pulmonary edema from rapid volume overload, coagulopathy, and acute renal impairment. Prompt recognition and management of these events are essential, and patients should be monitored closely during and after infusion.

Patients with known hypersensitivity to human albumin or any component of the formulation should not receive the product. Caution is also advised in individuals with severe heart failure, uncontrolled hypertension, or active bleeding disorders where rapid volume expansion could be harmful.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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