Nanocoloides De Albúmina Radiopharmacy (Human Serum Albumin)

Human Serum Albumin is employed in clinical situations that require plasma volume expansion or correction of low serum albumin.

• Hypovolemia: restores intravascular volume and improves hemodynamic stability.
• Hypoalbuminemia: raises serum albumin concentration in patients with liver disease, nephrotic syndrome or malnutrition.
• Major burns or extensive trauma: provides oncotic support and fluid balance during resuscitation.
• Cardiac surgery or cardiopulmonary bypass: maintains circulatory volume and reduces postoperative edema.
• Plasma exchange procedures: serves as a colloid replacement to sustain oncotic pressure.

• Human Serum Albumin acts as a natural plasma protein that exerts oncotic pressure, drawing water into the vascular compartment. By increasing colloid osmotic pressure, it expands intravascular volume, improves tissue perfusion, and stabilizes hemodynamics. The protein also serves as a carrier for endogenous substances such as hormones, fatty acids, and drugs, influencing their distribution and metabolism.

Human Serum Albumin may be associated with a range of adverse reactions, most of which are related to its protein nature and the intravenous route.

Common Side Effects

• Fever or chills during infusion.
• Mild hypotension or transient blood pressure changes.
• Nausea or vomiting.
• Headache.
• Rash or mild urticaria.
• Elevated serum calcium due to calcium content in some formulations.

Serious or Rare Side Effects

• Anaphylactic or severe allergic reactions, including bronchospasm.
• Acute hemolysis in patients with anti‑albumin antibodies.
• Volume overload leading to pulmonary edema.
• Transmission of infectious agents (theoretical risk).

Human Serum Albumin should be used with careful clinical assessment and monitoring.

• Assess volume status: avoid in patients at risk of fluid overload.
• Monitor for allergic reactions: discontinue infusion if severe hypersensitivity occurs.
• Evaluate cardiac function: use cautiously in heart failure.
• Check serum calcium levels: some preparations contain calcium.
• Use aseptic technique: prevent contamination during preparation.
• Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Human Serum Albumin can interact with other agents that affect fluid balance or protein binding.

Major Interactions (Avoid)

• Diuretics: may exacerbate hypovolemia if albumin is not adequately replaced.
• ACE inhibitors or ARBs: combined use can increase risk of hypotension.
• High‑dose calcium supplements: may lead to hypercalcemia with calcium‑containing albumin solutions.

Moderate Interactions (Monitor Closely)

• Vasopressors: dose adjustments may be needed due to changes in intravascular volume.
• Anticoagulants: altered plasma protein levels can affect drug binding and activity.
• Immunosuppressants: monitor for infection risk when albumin is used in critically ill patients.