Product image of Humatin (Paromomycin Sulfate) supplied by GNH India

Humatin

Active Ingredient:
Paromomycin Sulfate
Origin:
EU

Humatin (Paromomycin Sulfate)

Humatin is an oral, prescription‑only medication that contains the active ingredient paromomycin sulfate. It is marketed in the European Union and belongs to the aminoglycoside antibiotic class, used primarily for treating intestinal protozoal infections and certain bacterial diarrheas.

Manufacturer / TM Owner

Pfizer Italia S.R.L.

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Humatin is indicated for several gastrointestinal and parasitic conditions where the causative organisms are susceptible to paromomycin.

  • Intestinal amoebiasis caused by Entamoeba histolytica
  • Giardiasis (Giardia lamblia infection)
  • Travelers' diarrhea due to susceptible bacterial strains
  • Off‑label use for cutaneous leishmaniasis in some clinical settings
  • Prevention of infection in high‑risk travel scenarios

How It Works

  • Paromomycin sulfate binds to the 30S subunit of bacterial and protozoal ribosomes, disrupting the initiation of protein synthesis. This binding causes misreading of messenger RNA, leading to the production of nonfunctional or toxic peptides, ultimately inhibiting microbial growth and eliminating the infection.

Side Effects

Adverse reactions to Humatin vary in frequency and severity.

Common

  • Nausea
  • Vomiting
  • Diarrhea
  • Abdominal cramps
  • Metallic taste in the mouth
  • Mild skin rash

Serious

  • Severe allergic reactions (anaphylaxis, angioedema)
  • Ototoxicity (hearing loss, tinnitus)
  • Nephrotoxicity (renal impairment)
  • Severe electrolyte disturbances

Precautions & Warnings

Before prescribing Humatin, clinicians should consider several safety factors.

  • Assess renal function, especially in patients with pre‑existing kidney disease.
  • Use caution in individuals with known hearing impairment or vestibular disorders.
  • Monitor for signs of hypersensitivity during treatment.
  • Pregnancy and lactation status are unknown; weigh potential risks and benefits.
  • Adjust dosage in elderly patients due to altered pharmacokinetics.
  • Ensure the infection is confirmed to be susceptible to paromomycin before initiating therapy.

Avoid Interactions

Humatin may interact with other medicines, affecting efficacy or safety.

Avoid

  • Concurrent use of other nephrotoxic agents (e.g., aminoglycoside antibiotics, vancomycin, loop diuretics).
  • Co‑administration with ototoxic drugs (e.g., loop diuretics, certain chemotherapeutics).

Use with caution

  • Antacids containing magnesium or aluminum, which can reduce absorption.
  • Neuromuscular blocking agents, as paromomycin may potentiate their effects.
  • Other oral antibiotics that may alter gut flora and affect drug absorption.
  • Medications cleared renally, requiring dose adjustments based on renal function.

Frequently Asked Questions

Humatin is primarily prescribed for intestinal infections caused by protozoa such as Entamoeba histolytica (amoebiasis) and Giardia lamblia (giardiasis), as well as certain bacterial travelers' diarrhea.

Paromomycin sulfate is poorly absorbed from the gastrointestinal tract, making it effective for luminal infections without significant systemic exposure, unlike many other aminoglycosides that are given intravenously.

The pregnancy safety category for Humatin is unknown; clinicians should evaluate potential risks and benefits before prescribing to pregnant individuals.

Common adverse effects include nausea, vomiting, diarrhea, abdominal cramps, a metallic taste, and mild skin rash.

Yes, although rare, ototoxicity such as hearing loss or tinnitus can occur, especially with prolonged use or in patients with pre‑existing ear disorders.

Kidney function should be assessed before starting therapy and monitored during treatment, as paromomycin can cause nephrotoxicity in susceptible individuals.

Antacids containing magnesium or aluminum may reduce the oral absorption of paromomycin, potentially decreasing its effectiveness.

Humatin is a prescription‑only medication and is not available without a healthcare provider’s order.

If signs of a severe allergic reaction such as difficulty breathing, swelling of the face or throat, or rash occur, the patient should seek emergency medical attention immediately.

There are no specific dietary restrictions, but patients should avoid taking antacids containing magnesium or aluminum at the same time as Humatin.

Humatin has been used off‑label for cutaneous leishmaniasis in some clinical settings, but this use is not officially approved and should be considered only under specialist guidance.

The duration of therapy varies based on the infection severity and physician recommendation; a typical course for giardiasis often ranges from 5 to 7 days.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Paromomycin Sulfate

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT