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Humulin Regular

Active Ingredient:
Insulin Human
Origin:
EU

Humulin Regular (Insulin Human)

Humulin Regular is a prescription insulin human injection solution (strength not specified) that is administered subcutaneously. It contains the active ingredient insulin human, a synthetic form of the hormone produced by the pancreas. Marketed in the European Union, this short‑acting insulin is used to regulate blood glucose levels in patients with diabetes. It belongs to the insulin class of antidiabetic agents and is classified as a short‑acting, rapid‑onset formulation.

Manufacturer / TM Owner

Eli Lilly Sweden Ab

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Indications & Clinical Uses

Humulin Regular is indicated for the management of hyperglycemia in several diabetic conditions.

  • Type 1 diabetes mellitus
  • Type 2 diabetes mellitus
  • Gestational diabetes
  • As part of a basal‑bolus insulin regimen
  • For correction of elevated blood glucose levels before meals

How It Works

  • Humulin Regular contains insulin human, which binds to insulin receptors on cell membranes. This binding activates the receptor’s intrinsic tyrosine‑kinase activity, promoting translocation of glucose‑transport proteins (GLUT‑4) to the cell surface, thereby increasing glucose uptake in muscle and adipose tissue. It also suppresses hepatic gluconeogenesis and glycogenolysis, leading to reduced endogenous glucose production.

Side Effects

Adverse reactions to Humulin Regular may vary in frequency and severity.

Common

  • Hypoglycemia (low blood glucose)
  • Injection‑site pain or erythema
  • Weight gain

Serious

  • Severe hypoglycemia with neuroglycopenic symptoms
  • Anaphylactic or severe allergic reaction
  • Significant hypokalemia

Precautions & Warnings

When using Humulin Regular, several precautions should be considered to ensure safe and effective therapy.

  • Regularly monitor blood glucose levels and adjust dose as needed
  • Do not administer during episodes of hypoglycemia; treat low glucose first
  • Adjust dosing during illness, surgery, or changes in physical activity
  • Use caution in patients with renal or hepatic impairment
  • Evaluate risks and benefits during pregnancy and lactation
  • Store the product according to label instructions, protecting it from extreme temperatures

Avoid Interactions

Humulin Regular can interact with other medicines, affecting glucose control or increasing the risk of adverse events.

Avoid

  • Concurrent use of other rapid‑acting insulins or insulin analogues
  • Co‑administration with sulfonylureas or meglitinides without dose adjustment
  • Use of non‑selective beta‑blockers that may mask hypoglycemia symptoms

Use with caution

  • ACE inhibitors or angiotensin‑II receptor blockers
  • Thiazide diuretics, which may raise blood glucose
  • Oral contraceptives and hormone replacement therapy
  • Systemic corticosteroids
  • Alcohol consumption

Frequently Asked Questions

Humulin Regular is a short‑acting insulin that contains the active ingredient insulin human, a synthetic form of the hormone produced by the pancreas.

It is prescribed for type 1 diabetes mellitus, type 2 diabetes mellitus, and gestational diabetes when rapid glucose control is needed.

Humulin Regular is administered by subcutaneous injection, typically into the abdomen, thigh, or upper arm.

Yes, it is often combined with a long‑acting basal insulin as part of a basal‑bolus regimen to provide both background and mealtime glucose control.

The most common side effect is hypoglycemia, which occurs when blood glucose falls below normal levels.

Severe hypoglycemia requires immediate treatment with fast‑acting carbohydrates or glucagon and urgent medical attention.

Unopened vials should be stored in a refrigerator (2–8 °C). Once opened, they may be kept at room temperature for a limited period as specified on the label.

The pregnancy category is listed as unknown; clinicians should weigh potential benefits against risks and monitor glucose closely if used during pregnancy.

Concurrent use of other rapid‑acting insulins, sulfonylureas, meglitinides, or non‑selective beta‑blockers should be avoided without dose adjustments.

ACE inhibitors, thiazide diuretics, oral contraceptives, systemic corticosteroids, and alcohol may affect glucose control and should be used with caution.

Humulin Regular has a rapid onset and short duration of action, making it suitable for mealtime glucose control, whereas long‑acting insulins provide basal coverage over 24 hours.

Regular self‑monitoring of blood glucose, especially before meals and at bedtime, is recommended to adjust dosing and prevent hypoglycemia.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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