Hyalistil (Sodium Hyaluronate)

Hyalistil is employed as an ocular lubricant and viscoelastic adjunct in various eye‑care situations.

• To provide temporary relief of dryness and irritation associated with environmental factors or contact lens wear.
• As a protective coating during intra‑ocular surgeries such as cataract extraction to maintain anterior chamber stability.
• To support corneal epithelial healing after minor trauma, abrasions, or surface procedures.
• As an adjunct in the management of postoperative inflammation to enhance patient comfort.

• Sodium hyaluronate in Hyalistil acts as a high‑molecular‑weight viscoelastic polymer that binds water molecules, creating a hydrated gel layer on the ocular surface. This layer reduces shear stress, improves tear film stability, and mimics the natural extracellular matrix of the cornea. The viscoelastic properties also help maintain space within the anterior chamber during surgery, facilitating tissue manipulation and promoting epithelial cell migration for wound repair.

Adverse reactions to Hyalistil are generally mild, but ocular products can occasionally cause more significant effects.

Common

• Transient stinging or burning sensation upon instillation.
• Temporary blurred vision that resolves within minutes.
• Mild conjunctival redness or irritation.
• Slight increase in tear production.

Serious

• Persistent ocular inflammation or uveitis.
• Corneal epithelial defect or ulceration.
• Allergic hypersensitivity reaction presenting as swelling, itching, or rash.
• Severe pain or vision loss requiring immediate medical attention.

When considering Hyalistil, clinicians should evaluate patient history and ocular condition to minimize risk.

• Avoid use in patients with known hypersensitivity to sodium hyaluronate or any formulation components.
• Do not administer if the ocular surface is infected or inflamed until the condition is treated.
• Use caution in eyes that have undergone recent surgery; monitor for delayed healing.
• Contact lens wearers should remove lenses before instillation and wait before reinserting.
• Store the product according to the label, protecting it from light and extreme temperatures.
• Discard any vial that appears cloudy, discolored, or past its expiration date.

Hyalistil may interact with other ophthalmic agents, influencing efficacy or safety.

Avoid

• Simultaneous use with preservative‑containing eye drops that may increase ocular surface toxicity.
• Co‑administration with other viscoelastic devices during the same surgical procedure, which could lead to excessive intra‑ocular pressure.

Use with caution

• Topical corticosteroids; monitor for delayed wound healing.
• Antihistamine eye drops; assess for additive drying effect.
• Systemic medications that affect wound healing, such as chemotherapy agents, when surgery is planned.