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Hydralazine Hydrochloride (Hydralazine Hydrochloride)

Trade Name : Hydralazine Hydrochloride

Medical Purchasing Solutions, LLC

INJECTION

Strength 20 mg/mL

HYDRALAZINE HYDROCHLORIDE Arteriolar Vasodilation [PE],Arteriolar Vasodilator [EPC]

Delivery Process

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Product information is meant for

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Disclaimer

Trade Marks displayed in compliance with provisions of: Trademark Act, 1999 u/s 30 and 30 (1) of "Fair use"

GNH India is WHO GDP and ISO 9001 2015 Certified Pharmaceutical Wholesaler/ Supplier/ Exporters/ Importer from India of Hydralazine Hydrochloride (Hydralazine Hydrochloride) which is also known as Hydralazine Hydrochloride and Manufactured by Medical Purchasing Solutions, LLC. It is available in strength of 20 mg/mL per ml. Read more

Hydralazine Hydrochloride (Hydralazine Hydrochloride) is supplied for Tenders/ Emergency imports/ Un - licensed, Specials, Orphan drug/ Name patient line/ RLD supplies/ Reference listed drugs/ Comparator Drug/ Bio-Similar/ Innovator samples For Clinical trials.  Click to know price.     Read less

Packaging and Delivery

Validated Cold Chain Shipment

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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About GNH

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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  • No data
  • Rx only
  • Hydralazine Hydrochloride Injection, USP is an antihypertensive available in a 2 mL vial for intravenous and intramuscular administration.u00a0 Each mL of the sterile, nonpyrogenic colorless solution contains hydralazine hydrochloride USP, 20 mg; methylparaben NF, 0.65 mg; propylparaben NF, 0.35 mg; propylene glycol USP, 103.6 mg, and Water for Injection USP q.s.u00a0 The pH of the solution is 3.4 to 4.4. pH may be adjusted with hydrochloric acid and/or sodium hydroxide.u00a0 Hydralazine hydrochloride is 1-hydrazinophthalazine monohydrochloride, and its structural formula is:
  • u00a0n n n n u00a0n nn
  • Hydralazine hydrochloride USP is a white to off-white, odorless crystalline powder.u00a0 It is soluble in water, slightly soluble in alcohol, and very slightly soluble in ether.u00a0 It melts at about 275u00b0C, with decomposition.
  • Although the precise mechanism of action of hydralazine is not fully understood, the major effects are on the cardiovascular system.u00a0 Hydralazine apparently lowers blood pressure by exerting a peripheral vasodilating effect through a direct relaxation of vascular smooth muscle.u00a0 Hydralazine, by altering cellular calcium metabolism, interferes with the calcium movements within the vascular smooth muscle that are responsible for initiating or maintaining the contractile state.
  • The peripheral vasodilating effect of hydralazine results in decreased arterial blood pressure (diastolic more than systolic); decreased peripheral vascular resistance; and an increased heart rate, stroke volume and cardiac output.u00a0 The preferential dilatation of arterioles, as compared to veins, minimizes postural hypotension and promotes the increase in cardiac output.u00a0 Hydralazine usually increases renin activity in plasma presumably as a result of increased secretion of renin by the renal juxtaglomerular cells in response to reflex sympathetic discharge.u00a0 This increase in renin activity leads to the production of angiotensin II, which then causes stimulation of aldosterone and consequent sodium reabsorption.u00a0 Hydralazine also maintains or increases renal and cerebral blood flow.
  • The average maximal decrease in blood pressure usually occurs 10-80 minutes after administration of hydralazine hydrochloride injection.u00a0 No other pharmacokinetic data on hydralazine hydrochloride injection are available.
  • Severe essential hypertension when the drug cannot be given orally or when there is an urgent need to lower blood pressure.
  • Hypersensitivity to hydralazine, coronary artery disease, mitral valvular rheumatic heart disease.
  • In a few patients, hydralazine may produce a clinical picture simulating systemic lupus erythematosus including glomerulonephritis.u00a0 In such patients, hydralazine should be discontinued unless the benefit-to-risk determination requires continued antihypertensive therapy with this drug.u00a0 Symptoms and signs usually regress when the drug is discontinued but residua have been detected many years later.u00a0 Long-term treatment with steroids may be necessary (see n n n n ).n nn
  • No data
  • Adverse reactions with hydralazine hydrochloride are usually reversible when dosage is reduced.u00a0 However, in some cases it may be necessary to discontinue the drug.u00a0
  • The following adverse reactions have been observed, but there has not been enough systematic collection of data to support an estimate of their frequency.
  • Common:
  • Less Frequent:n- Array
  • Arrayn- Cardiovascular
  • Arrayn- Respiratory
  • Arrayn- Neurologic
  • Arrayn- Genitourinary
  • Arrayn- Hematologic
  • Arrayn- Hypersensitive Reactions
  • Arrayn- Other
  • No data
  • When there is urgent need, therapy in the hospitalized patient may be initiated intramuscularly or as a rapid intravenous bolus injection directly into the vein.u00a0 Hydralazine Hydrochloride Injection should be used only when the drug cannot be given orally.u00a0 The usual dose is 20-40 mg, repeated as necessary.
  • Certain patients (especially those with marked renal damage) may require a lower dose.u00a0u00a0 Blood pressure should be checked frequently.u00a0 It may begin to fall within a few minutes after injection, with the average maximal decrease occurring in 10-80 minutes.u00a0 In cases where there has been increased intracranial pressure, lowering the blood pressure may increase cerebral ischemia.u00a0 Most patients can be transferred to oral hydralazine hydrochloride within 24-48 hours.
  • The product should be used immediately after the vial is opened.u00a0 The product should not be added to infusion solutions.u00a0 Hydralazine Hydrochloride Injection may discolor upon contact with metal; discolored solutions should be discarded.u00a0
  • Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.
  • The container closure is not made with natural rubber latex.
  • Store at 20u00b0 to 25u00b0C (68u00b0 to 77u00b0F) [see USP Controlled Room Temperature].
  • No data
  • Hydralazine 1 mL Single Dose Vial Label
  • HydrALAZINE Hydrochloride
  • 2 n n
  • For IM or IV use.n n n Single Dose Vial Rx onlyn
  • NDC 71872-7145-1
  • Rx only
  • Hydralazine Hydrochloride Injection, USP
  • 20 mg/mL
  • 1 - 1 mL Single Dose Vial
  • For Intramuscular or Intravenous Use
  • Sterile

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Comparator Sourcing for Clinical Trials

Comparator Sourcing for Clinical Trials

GNH India brings over 10 years of experience in Comparator

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Name Patient Supply

Name Patient Supply

Today, the exact cause for many rare diseases remains unknown

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Validated Cold Chain Shipment

Validated Cold Chain Shipment

With shifting of pharma industry from synthetic molecules to biologic

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Clinical Trials Supply

Clinical Trials Supply

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Pharmaceutical Contract Manufacturing

Pharmaceutical Contract Manufacturing

GNH Provides Contract Manufacturing services for: Generic Medicines with following

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