Hydrex S (Chlorhexidine Digluconate Solution)

Hydrex S is indicated for a range of skin antisepsis applications where reduction of bacterial load is required. It is commonly employed in clinical and home settings to prepare the skin before invasive procedures, to cleanse minor wounds, and to maintain hygiene of surgical sites.

• Pre‑operative skin preparation for minor surgical or diagnostic procedures.
• Cleansing of superficial cuts, abrasions, and lacerations before dressing.
• Disinfection of intact skin prior to catheter or needle insertion.
• Reducing microbial colonisation on skin surrounding chronic wounds.
• Routine antiseptic hand‑rubbing in healthcare or community environments.

• Chlorhexidine digluconate exerts its antiseptic effect by binding to negatively charged bacterial cell walls and disrupting membrane integrity. The compound penetrates the lipid bilayer, causing leakage of intracellular contents and precipitation of cytoplasmic proteins. This loss of structural stability leads to rapid bacterial cell death across a broad spectrum of Gram‑positive and Gram‑negative organisms, including many skin‑associated pathogens. Its activity persists on the skin for several hours, providing prolonged protection against re‑contamination.

Topical application of chlorhexidine may be associated with local skin reactions, most of which are mild and reversible.

Common

• Mild erythema or redness at the application site.
• Transient itching or burning sensation during or shortly after use.
• Slight skin dryness or peeling in the treated area.
• Temporary discoloration or staining of the skin that resolves with washing.
• Minor swelling or edema that subsides within a few hours.

Serious

• Allergic contact dermatitis characterized by swelling, vesicles, or intense itching.
• Severe skin irritation leading to ulceration or necrosis, especially with prolonged exposure.
• Development of chemical burns if the solution contacts eyes or mucous membranes.
• Persistent irritation leading to secondary bacterial infection of the treated area.
• Rare systemic hypersensitivity reactions such as urticaria or anaphylaxis.

When using Hydrex S, certain precautions help minimize adverse reactions and ensure safe application.

• Perform a small patch test on intact skin before first use to assess tolerance.
• Avoid applying the solution to large open wounds, deep puncture sites, or mucous membranes.
• Keep away from eyes, ears, and mouth; rinse thoroughly if contact occurs.
• Do not use on patients with known hypersensitivity to chlorhexidine or related compounds.
• Store at room temperature, protected from light and extreme heat.
• Discontinue use and seek medical advice if signs of severe irritation or allergic reaction develop.
• Keep out of reach of children; supervise use in pediatric settings.

Chlorhexidine can interact with certain substances, potentially affecting its antiseptic efficacy or increasing irritation risk.

Avoid

• Do not combine with topical products containing alcohol, peroxide, or other antiseptics, as this may reduce antimicrobial activity.
• Avoid simultaneous use with ophthalmic or otic preparations, since chlorhexidine can cause severe irritation in these sites.

Use with caution

• Apply cautiously on patients receiving other skin irritants or sensitizing agents, monitoring for additive irritation.
• Use with care in individuals with compromised skin barrier, such as eczema, to prevent enhanced absorption.
• When used before catheter insertion, ensure the catheter material is compatible, as chlorhexidine may affect certain polymers.