Product image of Irbesartán/Hidroclorotiazida Almus (Hydrochlorothiazide, Irbesartan) supplied by GNH India

Irbesartán/Hidroclorotiazida Almus

Active Ingredient:
Hydrochlorothiazide, Irbesartan
Origin:
EU

Irbesartán/Hidroclorotiazida Almus (Hydrochlorothiazide, Irbesartan)

Irbesartan/Hydrochlorothiazide, the active ingredient in Irbesartán/Hidroclorotiazida Almus, is an angiotensin II receptor blocker / thiazide diuretic presented as a tablet for oral use. It treats hypertension in adult patients. GNH India supplies Irbesartán/Hidroclorotiazida Almus as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Almus Farmaceutica S.A.

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Indications & Clinical Uses

  • Irbesartan/Hydrochlorothiazide is used in the management of hypertension, targeting the renin‑angiotensin system and renal sodium handling.
  • Hypertension: reduces systolic and diastolic blood pressure in adults.
  • Resistant hypertension: provides additional control when monotherapy is insufficient.
  • Hypertension with edema: promotes diuresis to help manage fluid overload associated with high blood pressure.

How It Works

  • Irbesartan selectively blocks angiotensin II type 1 (AT1) receptors, preventing vasoconstriction and aldosterone secretion, while hydrochlorothiazide inhibits Na+/Cl‑ reabsorption in the distal convoluted tubule, increasing urinary excretion of sodium and water. The combined actions lower peripheral vascular resistance and plasma volume, resulting in reduced arterial pressure.

Side Effects

Common Side Effects

  • Dizziness or light‑headedness.
  • Headache.
  • Increased urination.
  • Mild electrolyte disturbances (e.g., low potassium).
  • Fatigue.
  • Gastrointestinal discomfort.

Serious or Rare Side Effects

  • Angioedema or severe allergic reaction.
  • Hyperkalemia or severe electrolyte imbalance.
  • Acute kidney injury.
  • Severe dehydration.
  • Hepatic injury.
  • Blood dyscrasias such as agranulocytosis.

Precautions & Warnings

Before initiating therapy, consider the following precautions:

  • Monitor electrolytes: check potassium and sodium levels regularly.
  • Assess renal function: evaluate serum creatinine and eGFR before and during treatment.
  • Avoid in severe hepatic impairment: use with caution or consider alternatives.
  • Pregnancy: contraindicated in the second and third trimesters due to fetal risk.
  • Drug interactions: review concomitant medications for additive potassium effects.
  • Store at ambient temperature: keep in the original pack, protect from moisture and light.

Avoid Interactions

Irbesartan/Hydrochlorothiazide may interact with several medicines.

Major Interactions (Avoid)

  • Potassium‑sparing diuretics: risk of hyperkalemia.
  • ACE inhibitors or ARBs combined with aliskiren in diabetic patients: increased renal risk.
  • Lithium: may raise lithium concentrations.
  • NSAIDs: can diminish antihypertensive effect and affect renal function.

Moderate Interactions (Monitor Closely)

  • Other antihypertensives: additive blood pressure lowering.
  • Corticosteroids: may increase potassium loss.
  • Beta‑blockers: monitor for excessive hypotension.

Frequently Asked Questions

Irbesartán/Hidroclorotiazida Almus is a fixed‑dose combination of irbesartan and hydrochlorothiazide indicated for the treatment of hypertension in adults. It helps lower blood pressure by blocking angiotensin II receptors and promoting diuresis, thereby reducing cardiovascular risk.

Irbesartan selectively blocks the angiotensin II type 1 (AT1) receptor, preventing the hormone from causing vasoconstriction and stimulating aldosterone release. This results in relaxed blood vessels, reduced sodium and water retention, and ultimately lower arterial pressure.

The specific dose is determined by the prescribing clinician based on the patient’s blood pressure, renal function, and other medications. The product is supplied as oral tablets in defined strengths, and the prescriber selects the appropriate strength and dosing schedule.

Use during pregnancy, especially in the second and third trimesters, is generally contraindicated because of potential fetal harm. Safety during breastfeeding has not been established, so the medication should be avoided unless the benefit to the mother clearly outweighs the potential risk to the infant.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with monotherapy, the irbesartan/hydrochlorothiazide combo offers dual mechanisms—vascular relaxation and diuresis—allowing better blood‑pressure control in patients who need more than one agent, while reducing pill burden versus taking separate tablets of each component.

The tablets should be stored at ambient temperature, below 25 °C, in the original packaging, protected from moisture, light and excessive heat. Proper storage helps maintain the product’s potency throughout its shelf‑life.

The medication is taken orally, usually once daily in the morning, with or without food, as directed by a healthcare professional. The tablet should be swallowed whole with a glass of water; it is not intended for crushing or chewing.

Patients should be alert for severe allergic reactions such as facial or throat swelling, marked drops in blood pressure, significant electrolyte disturbances like hyperkalemia, and signs of kidney impairment. Any of these symptoms require immediate medical evaluation.

Individuals with known hypersensitivity to irbesartan, hydrochlorothiazide or any excipients, those with severe renal or hepatic impairment, and pregnant women in the second or third trimester should avoid this product unless a physician determines it is essential.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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