Product image of Irbesartán/Hidroclorotiazida Cinfa (Hydrochlorothiazide, Irbesartan) supplied by GNH India

Irbesartán/Hidroclorotiazida Cinfa

Active Ingredient:
Hydrochlorothiazide, Irbesartan
Origin:
EU

Irbesartán/Hidroclorotiazida Cinfa (Hydrochlorothiazide, Irbesartan)

Irbesartan/Hydrochlorothiazide, the active ingredient in Irbesartán/Hidroclorotiazida Cinfa, is an angiotensin II receptor blocker and thiazide diuretic presented as a tablet for oral use. It treats hypertension in adult patients.
GNH India supplies Irbesartán/Hidroclorotiazida Cinfa as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Laboratorios Cinfa S.A.

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Indications & Clinical Uses

Irbesartan/Hydrochlorothiazide is used to manage high‑blood‑pressure conditions within the antihypertensive drug class.

  • Essential hypertension: lowers systolic and diastolic blood pressure to target levels.
  • Hypertension requiring diuretic therapy: adds diuretic effect to improve blood‑pressure control.
  • Hypertension with fluid retention: reduces plasma volume and vascular resistance for better control.

How It Works

  • Irbesartan selectively blocks AT1 receptors, preventing angiotensin II‑mediated vasoconstriction and aldosterone release. Hydrochlorothiazide inhibits NaCl reabsorption in the distal convoluted tubule, promoting natriuresis and diuresis, which together lower peripheral resistance and plasma volume, resulting in reduced arterial pressure.

Side Effects

Adverse reactions may occur with any antihypertensive combination therapy.

Common Side Effects

  • Dizziness or light‑headedness.
  • Headache.
  • Fatigue.
  • Increased urination.
  • Electrolyte disturbances (e.g., low potassium).
  • Mild gastrointestinal upset.

Serious or Rare Side Effects

  • Severe hypotension.
  • Acute kidney injury.
  • Hyperkalemia.
  • Angioedema.
  • Hepatic dysfunction.
  • Severe electrolyte imbalance (e.g., hyponatremia).

Precautions & Warnings

Before initiating therapy, consider the following safety measures.

  • Renal impairment: monitor kidney function and adjust therapy as needed.
  • Electrolyte balance: check serum potassium and sodium regularly.
  • Pregnancy: avoid use unless clearly needed; discuss risks with a healthcare professional.
  • Concomitant drugs: review all medications for potential interactions.
  • Elderly patients: start at lower doses and monitor closely for orthostatic effects.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture.

Avoid Interactions

Irbesartan/Hydrochlorothiazide may interact with several drug classes.

Major Interactions (Avoid)

  • Potassium‑sparing diuretics or supplements: risk of hyperkalemia.
  • Lithium: increased lithium levels and toxicity.
  • NSAIDs: may reduce antihypertensive effect and impair renal function.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or other ARBs: additive risk of renal dysfunction.
  • Antidiabetic agents: may require dose adjustment due to blood‑glucose changes.
  • Antihypertensive agents (beta‑blockers, calcium channel blockers): monitor for excessive blood‑pressure lowering.

Frequently Asked Questions

Irbesartán/Hidroclorotiazida is a fixed‑dose combination of irbesartan and hydrochlorothiazide indicated for the treatment of hypertension in adult patients, helping to lower elevated blood‑pressure readings and reduce cardiovascular risk.

Irbesartan blocks the angiotensin II type‑1 (AT1) receptors, preventing vasoconstriction and aldosterone release, which leads to relaxation of blood vessels and reduced blood‑pressure levels.

The specific dose is determined by the prescribing clinician based on the patient’s blood‑pressure profile, renal function, and concomitant therapies. Dosage adjustments are individualized and should follow the prescriber’s instructions.

Use during pregnancy is generally discouraged unless the potential benefit outweighs the risk, as safety data are limited. Breastfeeding mothers should consult their healthcare provider, as the drug may pass into milk.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with single‑agent therapies, the combination offers dual mechanisms—AT1‑receptor blockade and diuresis—providing more potent blood‑pressure reduction in patients who need both actions, often simplifying dosing regimens.

Store the tablets at room temperature, below 25 °C, in the original container, protected from moisture and direct sunlight to maintain product stability.

The medication is taken orally, usually once daily, with or without food, as directed by the prescribing healthcare professional.

Serious adverse events can include severe hypotension, acute kidney injury, hyperkalemia, angioedema and significant electrolyte disturbances; patients should be monitored for these conditions.

Patients with known hypersensitivity to irbesartan, hydrochlorothiazide, or any component of the formulation, as well as those with severe renal impairment, uncontrolled hyperkalemia, or a history of angioedema, should avoid this medication.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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