Product image of Irbesartán/Hidroclorotiazida Sun (Hydrochlorothiazide, Irbesartan) supplied by GNH India

Irbesartán/Hidroclorotiazida Sun

Active Ingredient:
Hydrochlorothiazide, Irbesartan
Origin:
EU

Irbesartán/Hidroclorotiazida Sun (Hydrochlorothiazide, Irbesartan)

Irbesartan/Hydrochlorothiazide, the active ingredients in Irbesartán/Hidroclorotiazida Sun, are an Angiotensin II receptor blocker and a thiazide diuretic presented as tablets for oral use. They treat hypertension by combining vasodilation and diuretic mechanisms to lower blood pressure in adults.
GNH India supplies Irbesartán/Hidroclorotiazida Sun as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sun Pharmaceutical Industries Europe B.V.

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Indications & Clinical Uses

  • Irbesartan/Hydrochlorothiazide is used in the management of hypertension, a condition characterized by elevated arterial pressure.
  • Hypertension: lowers systolic and diastolic blood pressure, helping to reduce cardiovascular risk.

How It Works

  • Irbesartan selectively blocks AT1 receptors, preventing angiotensin II from causing vasoconstriction and aldosterone release. Hydrochlorothiazide inhibits sodium‑chloride reabsorption in the distal convoluted tubule, increasing urinary excretion of water and electrolytes. The combined effect reduces peripheral vascular resistance and plasma volume, resulting in lowered arterial pressure.

Side Effects

Like all medicines, Irbesartan/Hydrochlorothiazide may cause unwanted reactions.

Common Side Effects

  • Dizziness or light‑headedness
  • Headache
  • Fatigue or weakness
  • Increased urination
  • Mild nausea or abdominal discomfort
  • Electrolyte changes such as low potassium

Serious or Rare Side Effects

  • Angioedema (swelling of face, lips, tongue)
  • Severe dehydration or electrolyte imbalance
  • Acute kidney injury or worsening renal function
  • Hyperkalemia (high potassium levels)
  • Marked hypotension (very low blood pressure)
  • Severe allergic skin reactions (e.g., Stevens‑Johnson syndrome)

Precautions & Warnings

Before prescribing Irbesartan/Hydrochlorothiazide, clinicians should consider the following precautions.

  • Renal function: assess baseline kidney function and monitor creatinine levels
  • Electrolytes: regularly check serum potassium and sodium concentrations
  • Pregnancy: avoid use because of potential fetal harm
  • Concomitant NSAIDs: may reduce antihypertensive efficacy and affect renal function
  • Gout: thiazide component can increase serum uric acid
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Irbesartan/Hydrochlorothiazide can interact with several other medicines.

Major Interactions (Avoid)

  • Potassium‑sparing diuretics or supplements: risk of hyperkalemia
  • Lithium: increased lithium levels and potential toxicity
  • ACE inhibitors or other ARBs combined: additive renal effects
  • Aliskiren in diabetic patients: heightened risk of renal impairment
  • Strong CYP2C9 inhibitors (e.g., fluconazole): may raise irbesartan concentrations

Moderate Interactions (Monitor Closely)

  • NSAIDs: may blunt the antihypertensive response
  • Additional thiazide diuretics: additive electrolyte disturbances
  • Antidiabetic agents: blood glucose may fall, requiring dose adjustment
  • Beta‑blockers: may enhance blood‑pressure lowering effect
  • Antacids containing aluminum or magnesium: may affect drug absorption

Frequently Asked Questions

Irbesartán/Hidroclorotiazida Sun is a fixed‑dose combination of irbesartan and hydrochlorothiazide indicated for the treatment of hypertension. It helps lower elevated blood pressure by combining vasodilation with increased urinary water and salt excretion.

Irbesartan blocks the angiotensin II type 1 (AT1) receptors, preventing the hormone from causing blood‑vessel constriction and aldosterone‑mediated fluid retention. This results in vasodilation and reduced blood‑volume pressure, contributing to overall blood‑pressure control.

The appropriate dose is determined by the prescribing clinician based on the patient’s blood‑pressure level, renal function, and other clinical factors. Dosage adjustments are made individually and should follow the prescriber’s instructions.

Use during pregnancy is generally contraindicated because angiotensin‑II receptor blockers can cause fetal toxicity. Safety in breastfeeding has not been established, so the medication should be avoided unless the benefits outweigh the potential risks.

Enquiries are submitted via the product page on gnhindia.com, where you specify the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

The irbesartan/hydrochlorothiazide combo offers dual mechanisms—angiotensin‑II blockade and thiazide‑induced diuresis—in a single tablet, which can simplify regimens compared with separate agents. It is often chosen when monotherapy does not achieve target blood pressure.

Store the tablets at ambient temperature, below 25 °C, in the original blister or container. Keep them away from moisture, heat and direct sunlight to maintain product stability.

The medication is taken orally, usually once daily, with or without food, as directed by the prescriber. Swallow the tablet whole with a glass of water; do not crush or chew it.

Serious adverse events include angioedema, severe dehydration, acute kidney injury, hyperkalemia, and marked hypotension. Patients should seek immediate medical attention if they experience swelling of the face or throat, rapid weight loss, reduced urine output, or fainting.

The combination is contraindicated in patients with known hypersensitivity to irbesartan, hydrochlorothiazide, or any component of the formulation, as well as in individuals with severe renal impairment, hyperkalemia, or those who are pregnant.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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