Hydrocortisone 1%w/W Cream Pinewood Laboratories (Hydrocortisone)

Hydrocortisone 1% cream is indicated for a variety of mild to moderate inflammatory skin conditions where reduction of redness, swelling, and itching is desired. It is applied to the affected area two to three times daily, or as directed by a healthcare professional, and is generally intended for short‑term use to control symptoms.

• Eczema (atopic dermatitis) flare‑ups.
• Contact dermatitis caused by irritants or allergens.
• Mild psoriasis plaques.
• Insect bite reactions with localized swelling.
• Allergic skin reactions such as hives limited to small areas.
• Minor sunburn with erythema.
• Post‑procedural skin irritation (e.g., after minor cuts or abrasions).

• Hydrocortisone exerts its anti‑inflammatory and immunosuppressive actions by diffusing into skin cells and binding to intracellular glucocorticoid receptors. The receptor‑ligand complex translocates to the nucleus, where it modulates gene transcription, up‑regulating anti‑inflammatory proteins such as annexin‑1 and down‑regulating pro‑inflammatory cytokines, chemokines, and adhesion molecules. This results in decreased vascular permeability, reduced leukocyte migration, and suppression of the local immune response.

Topical hydrocortisone may cause local skin reactions; most are mild and reversible after discontinuation.

Common

• Mild burning, stinging, or tingling sensation at the site of application, usually resolving within minutes.
• Slight itching, dryness, or tightness of the skin that improves after a few days.
• Redness or mild irritation that may appear as a faint pink hue around the treated area.
• Peeling, flaking, or scaling of the skin surface, especially with prolonged use.

Serious

• Noticeable thinning of the skin, easy bruising, or development of stretch marks indicating local atrophy.
• Contact dermatitis or allergic reaction characterized by intense redness, swelling, and possible vesicle formation.
• Signs of systemic absorption such as unexplained fatigue, dizziness, or hormonal effects, although rare with short‑term topical use.
• Secondary bacterial or fungal infection of the area, presenting with increased pain, pus, or spreading redness.

When using hydrocortisone 1% cream, certain precautions help minimize risks and ensure safe application.

• Avoid applying to broken, infected, or ulcerated skin unless directed by a clinician.
• Do not use on large surface areas or for longer than recommended without medical supervision.
• Keep the product away from eyes, mouth, and mucous membranes; if accidental contact occurs, rinse thoroughly with water.
• Limit use on the face, genital area, or underarms, as these sites are more prone to thinning.
• Discontinue use and seek advice if signs of worsening irritation, rash, or systemic effects appear.

Hydrocortisone cream can interact with other topical agents or systemic medications that affect skin integrity or hormone balance.

Avoid

• Concurrent use with other potent topical corticosteroids or combination products containing steroids, as this may increase the risk of skin atrophy.
• Application over areas treated with occlusive dressings or bandages that enhance absorption, unless specifically advised.

Use with caution

• Systemic corticosteroids or oral glucocorticoids, because additive immunosuppressive effects may occur.
• Antifungal or antibacterial creams applied to the same site, which could alter local irritation or absorption.
• Photosensitizing agents (e.g., retinoids) where combined use may increase skin sensitivity to sunlight.