Hydrocortison Léčiva (Hydrocortisone Acetate)

Hydrocortison Léčiva is used as a topical therapy for a range of inflammatory and allergic skin disorders.

• Mild to moderate atopic dermatitis, providing relief from redness and itching.
• Chronic eczema flare‑ups, helping to reduce scaling and inflammation.
• Plaque psoriasis lesions, used to soften plaques and diminish erythema.
• Contact dermatitis caused by irritants or allergens, applied to calm the affected area.
• Seborrheic dermatitis of the scalp or face, assisting in controlling flaking and irritation.

• Hydrocortison Léčiva delivers hydrocortisone acetate to the skin, where it penetrates epidermal cells and binds to intracellular glucocorticoid receptors. The receptor‑drug complex translocates to the nucleus and modulates gene transcription, leading to inhibition of phospholipase A2 and reduced synthesis of prostaglandins and leukotrienes. This cascade suppresses the release of inflammatory cytokines such as interleukin‑1 and tumor‑necrosis factor‑α, thereby decreasing local inflammation and allergic responses.

Topical application of Hydrocortison Léčiva may cause local skin reactions, most of which are mild and reversible.

Common

• Burning or stinging sensation where the cream is applied.
• Mild itching, dryness or peeling of the treated skin.
• Slight redness (erythema) that usually subsides with continued use.
• Temporary skin thinning (atrophy) after extended treatment.

Serious

• Development of secondary bacterial, fungal or viral skin infections.
• Allergic contact dermatitis manifesting as swelling, rash, or vesicles.
• Systemic corticosteroid effects such as adrenal suppression when large areas are treated for prolonged periods.

Before using Hydrocortison Léčiva, consider the following precautions to minimize risks and ensure appropriate therapy.

• Avoid application on broken, infected, or ulcerated skin unless directed by a clinician.
• Do not use on the face, groin, or underarms for extended periods without medical supervision.
• Limit treatment duration and surface area to reduce the chance of skin atrophy.
• Discontinue use and seek medical advice if signs of an allergic reaction appear.
• Pregnant or breastfeeding individuals should consult a healthcare professional before use.
• Children under 12 years of age may be more susceptible to systemic absorption; use only as prescribed.
• Avoid concurrent use of other potent topical steroids on the same area.

Hydrocortison Léčiva can interact with other topical or systemic agents, affecting efficacy or safety.

Avoid

• Avoid simultaneous application of other potent corticosteroids on the same skin region, which can increase risk of atrophy.
• Do not combine with occlusive dressings unless instructed, as they may enhance systemic absorption.

Use with caution

• Use cautiously with topical calcineurin inhibitors; alternating therapy may reduce irritation risk.
• Caution when used with antiviral or antifungal creams, as steroid may mask infection signs.
• When patients are on systemic corticosteroids, monitor for additive systemic effects.
• Caution with photosensitizing agents; steroid may alter skin response to UV exposure.