Hydrocortisone Northumbria Pharma Ltd (Hydrocortisone)

Hydrocortisone Northumbria Pharma Ltd is indicated for the topical treatment of several inflammatory skin disorders. It helps reduce redness, swelling, and itching associated with these conditions.

• Mild to moderate dermatitis, including contact and atopic forms
• Eczema flare‑ups and maintenance therapy
• Psoriasis plaques that respond to low‑potency steroids
• Other localized inflammatory skin conditions such as seborrheic dermatitis or minor allergic reactions
• Short‑term relief of itching and irritation from insect bites or minor abrasions

• Hydrocortisone exerts its anti‑inflammatory and immunosuppressive actions by binding to intracellular glucocorticoid receptors. The activated receptor complex translocates to the nucleus, where it modulates gene transcription, decreasing the production of pro‑inflammatory cytokines, prostaglandins, and leukotrienes. This results in reduced vascular permeability, inhibition of leukocyte migration, and overall suppression of the inflammatory response in the skin.

Adverse reactions to topical hydrocortisone are generally mild but can vary with duration of use and skin area treated.

Common

• Mild skin irritation or burning sensation at the application site
• Pruritus or itching unrelated to the underlying condition
• Dryness or peeling of the treated skin
• Minor erythema or flushing

Serious

• Contact dermatitis or allergic reaction to the formulation
• Skin atrophy or thinning with prolonged use
• Striae (stretch marks) in susceptible individuals
• Secondary infection of the skin, including bacterial, fungal, or viral

When using Hydrocortisone Northumbria Pharma Ltd, certain safety considerations should be observed to minimize risks.

• Limit application to the prescribed area and avoid excessive or prolonged use.
• Do not apply to broken, infected, or ulcerated skin without medical guidance.
• Use caution on thin skin areas such as the face, groin, or axillae to reduce the risk of atrophy.
• Pregnant or breastfeeding individuals should consult a healthcare professional before use.
• Discontinue use and seek medical advice if signs of an allergic reaction or worsening skin condition occur.
• Keep the product out of reach of children; accidental ingestion can be harmful.

Topical hydrocortisone may interact with other skin‑applied agents or systemic medications that affect corticosteroid metabolism.

Avoid

• Concurrent use of other potent topical steroids on the same area, which can increase systemic absorption.
• Application of occlusive dressings that trap heat and enhance drug penetration.

Use with caution

• Systemic corticosteroids, as combined effects may increase the risk of systemic side effects.
• Antifungal or antibacterial creams, which may alter skin barrier function.
• Non‑steroidal anti‑inflammatory drugs (NSAIDs) applied topically, potentially increasing local irritation.
• Herbal or cosmetic products containing irritants that could exacerbate skin reactions.