Hydrocortisonum Aflofarm (Hydrocortisone Acetate)

Hydrocortisonum Aflofarm is indicated for the topical management of several inflammatory skin conditions. It is applied to the affected area to lessen redness, swelling, and itching.

• Eczema (atopic dermatitis): mild to moderate flare‑ups of dry, itchy skin.
• Contact dermatitis: reactions caused by irritants or allergens on the skin surface.
• Psoriasis: plaque lesions with scaling and inflammation.
• Seborrheic dermatitis: areas of flaky, red skin, especially on scalp or face.
• Other inflammatory dermatoses: such as lichen planus or discoid lupus erythematosus.

• Hydrocortisonum Aflofarm delivers hydrocortisone acetate to the skin, where it penetrates keratinocytes and binds intracellular glucocorticoid receptors. The receptor‑drug complex translocates to the nucleus and modulates gene transcription, leading to inhibition of phospholipase A2 and reduced synthesis of prostaglandins and leukotrienes. This cascade diminishes the release of inflammatory cytokines and mediators, producing anti‑inflammatory and immunosuppressive effects at the site of application.

Topical hydrocortisone acetate may cause local or systemic adverse reactions, although many users experience no problems.

Common

• Skin irritation or burning sensation at the application site
• Dryness or peeling of the treated skin
• Mild itching or rash
• Folliculitis or acneiform eruptions
• Redness (erythema) that may persist after treatment
• Hyperpigmentation or hypopigmentation of the skin

Serious

• Thinning of the skin (atrophy) with prolonged use
• Development of stretch marks (striae)
• Secondary infection of the skin, including bacterial, fungal, or viral
• Systemic absorption leading to adrenal suppression (rare)
• Allergic contact dermatitis

Before using Hydrocortisonum Aflofarm, certain precautions should be considered to minimize risks and ensure safe application.

• Avoid application on broken, infected, or ulcerated skin unless directed by a healthcare professional.
• Do not use on large body surface areas or for prolonged periods without medical supervision.
• Limit use on the face, intertriginous areas, or genital skin to reduce risk of atrophy.
• Discontinue if signs of hypersensitivity such as rash, swelling, or severe burning occur.
• Pregnant or breastfeeding individuals should consult a physician before use.
• Children may be more susceptible to systemic effects; use the lowest effective amount.
• Store at room temperature, protected from light and moisture.

Hydrocortisonum Aflofarm can interact with other topical or systemic agents, influencing its efficacy or safety.

Avoid

• Concurrent use of other potent topical corticosteroids on the same area.
• Application of occlusive dressings that increase drug absorption.
• Use with skin‑irritating chemicals such as harsh soaps or solvents.

Use with caution

• Systemic corticosteroids, which may add to systemic glucocorticoid load.
• Antifungal or antibacterial creams, as they may mask infection.
• Phototherapy or UV exposure, which can increase risk of skin atrophy.